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Curriculum Vitae view

Personal Details
Name :    Shehata M.El-Sewedy
Department :    Applied Medical Chemistry
Date of Birth :    August,9th,1943
Country of Birth :    Egypt
Job :    Professor of Medical Chemistry
E-mail :    drelsewedy@hotmail.com

Affiliation
Member in:
National Committee Of Biochemistry,Academy Of Scientific Research and Technology,Egypt.
Egyptian Society for Biochemistry
Egyptian Society for Toxicology
Medical Society in Alexandria

Qualification
1)1965: B.Sc. (Hons.), Special Chemistry, Faculity of Science,Alexandria University.

2)1969: M.Sc. Degree in Applied Organic Chemistry,Faculity of Sciences, Cairo University.

3)1973: Ph.D. in Biochemistry, Faculity of Science,Al-Azhar University.


Appointments
1) 1985-1991: Vice Dean for Post Graduate Studies and Research,Medical Research Institute,Alexandria University.
2) 1991: Vice Dean for Environmental Affairs and Community Development,Medical Research Institute,Alexandria University.
3) 1993-1999: Dean,Medical Research Institute,Alexandria University.
4) 2009 -Until now,Dean,Faculty of Allied Medical Science,Pharos University,Alexandria.Egypt

Courses, Meetings & Conferences
-International Training Course, Supported by UNSCO/ICRO,on Selected Topical of Modern Biology.In the field of Enzymology Budapest,Hungary,November1973-September1974.
-Postgraduate course in Cancerology"-sposored by American Cancer Society,Inc.,NewYork,USA,Medical Research Institute and Anticancer Association and Patient's care,Alexandria University.Egypt,22-24 December 1975.
-The Fourth Annual Scientific Congress on Cancer, 28-30 june 1978.
-The Second Medical Researches Congress,Medical Research Institute, Alexandria University ,1-6 July1978.
-The Global Fourth Scientific Congress for Cancer Prevention and Detection in London, England,26-31 July 1980.
-The Global Scientific Congress for Tryptophan,Japan,4-7 August 1980.
-The Scientific Mission,Arkansan University,USA,1982-1983.
-The Second National Conference for Biochemistry in Cairo,12-14 November 1985.
-The Third Conference Secretariat for Medical Research,Medical Research Institute,Alexandria University,25-27 October 1986.
-The Second Scientific Conference for Cancer,Abu-Zabbie,13-18 February 1987.
-The Head of the Seventh conference for Medical Research and the third Italian-Egyptian Workshop"Society and Environment" 29-30 October 1994.
-The Head of the eight-th conference for Medical Research and the Foruth Italian-Egyptian Workshop"Society and Environment",26-27 October 1996.
-The Head of Global Congress for Infectious Diseases and General Health,Alexandria,17-20 October 1997.

Publications
1- Abel-Tawab GA,El-Zoughby SM.Abdel Samie YM.Zaki AH,kholief TS and El-Sewedy SM.Urinary B-glucuronidase activity in some bilharzial urinary diseases.Trans Roy Trop Med Hyg 1968;62:501.
2- Abdel-Tawab GA, Kholief TS, El-Sewedy SM, Abassy AS, Zeitoun MM, and Hassanein EA. Studies on tryptophan metabolism in bilharzial hepatic fibrosis and non-bilharzial hepatic cirrhosis in childhood. Acta Pediat Scand 1969; 58: 54.

3- Abdel-Daim MH, El-Sewedy SM and Kalada FS. Tryptophan metabolism in patients with Schistosomiasis. Trans Roy Trop Med Hyg 1969; 63: 859.

4- Abassy AS, Zeitoun MM, Hassanein EA, Abdel-Tawab GA, Kholief TS and El-Sewedy SM. Studies on tryptophan metabolism in protein-calorie malnutrition. Trans Roy Trop Med Hyg 1970; 64: 148.

5- Abdel-Tawab GA, Abdel-Daim MH and El-Sewedy SM. Possible mechanism by which 5 antischistosomal drugs inhibition to some vitamin B6-dependent enzymatic reactions. First European Biophysics Congress, 14-17 September, 1971. Baden, near Vienna, Proceedings, Vol. 1, pp. 209.

6- El-Sewedy SM, Abdel-Tawab GA, Abdel-Daim MH and El-Sawy MF. Studies with tryptophan metabolites in vitro: Effect of methansulphonate derivatives of hycanthone (Etrenol) and lead acetate on kynureninase and kynurenine transaminase of normal mouse liver. Biochem Pharmacol 1972; 21: 379.

7- El-Sewedy SM, Abdel-Tawab GA, El-Zoughby SM, Zeitoun MM, Mostafa MH and Shalaby ShM. Studies with tryptophan metabolites in vitro: Effect of zinc, manganese, copper, cobalt ions on kynureninase and kynurenine transaminase of normal mouse liver. Biochem Pharmacol 1974; 23: 2557.

8- El-Zoughby SM, El-Sewedy SM, Saad AA, Moustafa MH, Ebied SM and Abdel-Tawab GA. In vitro trials to counteract the inhibitory effect of oestradiol aminotransferase enzyme. Biochem Pharmacol 1976; 25: 2411.

9- Telegdi M, Fabian F, El-Sewedy SM and Strub FB. Micro-heterogenesity in porcine pancreatic amylase preparations due to disulfide-sulfhydryl exchange. Biochem Biophys Acta 1976; 429:860.

10- Moustafa MH, El-Sewedy SM, El-Zoughby SM, Saad AA, El-Kabriti H and Rakonozay Z. In vitro effect of some naturally secreted hormones on tryptophan hydroxylase activity of Bee adrenal medulla. Aggressologie 1977; 18: 5.

11- Saad AA, El-Zoughby SM, Farag HF, El-Sewedy SM, Girgis LH and Moghazy M. Biochemical studies on -glucuronidase in urinary bladder of normal Schistosoma manosoni infected mice treated with hycanthone. Acta Vitaminol et Enzymol 1977; 31: 183.

12- Saad AA, El-Zoughby SM, El-Sewedy SM, Girgis LH, Farag HF and Moghazy M. Biochemical studies on -glucuronidase enzyme in liver and spleen homogenates of normal Schistosoma manosoni infected mice treated with hycanthone. Biochem Pharmacol 1978; 27: 473.

13- El-Sewedy SM, Arafa AM, Abdel-Aal G and Mostafa MH. The activities of urinary alpha-esterases in bilharziasis and their possible role in the diagnosis of bilharzial bladder cancer in Egypt. Trans Roy Trop Med Hyg 1978; 72: 525.

14- El-Sewedy SM, Al-Bassiouni EA, and Assar ST. Effect of some steroids on bovine pancreatic ribonuclease activity in vitro. Biochem Pharmacol 1978, 27: 1031.

15- El-Sewedy SM, Abdel-Tawab GA, Zaki A, Zeitoun MM, Hammam MA, Kantoosh M and Abdel Moneim MA. The activity of serum RNase in protein-energy malnutrition. Trans Roy Soc Trop Med Hyg 1978; 72: 529.

16- Zeitoun MM, Hammam MA, Kantoosh M, Abdel Moneim MA and El-Sewedy SM. Serum and urinary ribonuclease in children with bilharzial hepatic fibrosis. Trans Roy Soc Trop Med Hyg 1978; 72: 631.
17- El-Sewedy SM, Mostafa MH, Saad AA, El-Zoughby SM, El-Kabarirti, El-Dardiry N, Marie S, El-Sahwi S, Kira L and Rizk M. The effect of naturally secreted hormones on the activity of ribonuclease enzymes. Tanta J Med 1978; 6: 237.

18- El-Zoughby SM, El-Sewedy SM, Saad AA, Mostafa MH, El-Kholy ZA, El-Toukhy MA and Abdel-Tawab GA. In vitro studies of the effect of metal ions. EDTA and their mixtures on kynurenine aminotransferase and kynurenine hydroxylase. Acta Vitaminol et Enzymol 1978; 32: 145.

19- El-Zoughby SM, El-Kholy ZA, El-Sewedy SM and Abdel-Tawab GA. The spontaneous urinary excretion of tryptophan metabolites “via kynurenine” in women with regards to the prepuberty, sexual maturity and menopause. Acta Vitaminol Enzymol 1978; 32: 155.

20- Abdel-Kader HM, Mosehli M, El-Sewedy SM, Mahfouz M, El-Sadik YM and Dakhakhny A. Some biochemical and haematological changes in occupational exposure to mercury vapour. Hig Rada Toksikol 1978; 30: 267.

21- El-Sewedy SM, Soffar AM, Sallam N, El-Melegy S, Abdel-Rafee A and El-Darderi N. Serum free alkaline ribonuclease activity in pregnant and non-pregnant females. Tanta Med J 1979; 7:273.

22- El-Sewedy SM, Soffar AM, Sallam N, El-Melegy S and Abdel-Rafee A. The activity of free alkaline ribonuclease and non-specific -esterases in liver and spleen of S. mansoni. Tanta Med J 1979; 7: 259.

23- El-Sewedy SM, Mostfa MH, El-Hammay NH and Abdel-Tawab GA. Effect of lead on the activation energy and thermodynamic parameters of kynurenine aminotransferase and kynurenine hydrolase. Tanta Med J 1979; 7: 280.

24- Mostafa MH, El-Sewedy SM and Rakonozay Z. Effect of chlorpromazine free radical on tyrosine hydroxylase of bovine adrenal medulla. Agressologie 1979; 20: 275.

25- Saad AA, El-Zoughby SM, El-Sewedy SM and El-Kholy ZA. Biochemical studies on the effect of duration of oral contraceptive administration on -glucuronidase enzyme activity of serum and vaginal fluid. Bull Alex Med 1979; 15: 615.
26- Al-Bassiouni EA, El-Sewedy SM and Mostafa MH. The effect of some steroids and prostaglandins on the activity of -glucuronidase. J Med Res Inst 1980; 1: 109.

27- El-Sewedy SM, Zahran M, El-Melegy S, Akhnoukh S and Abdel-Rafee. The effect of some anti-cancer drugs on the activity of bovine liver -glucuronidase enzyme. J Med Res Inst 1980; 1: 115.

28- Soffar AM, El-Sewedy SM, Sallam N, Hassan SA and El-Melegy S. Effect of chlorpromazine and impramine on the liver function of rabbits with bilharzial hepatic fibrosis. J Med Res Inst 1980; 1: 145.

29- El-Sewedy SM and Abdel-Kader HM. Effect of exposure to mercury vapour below and above the Threshold Limit Value on some enzymatic activities. J Med Res Inst 1980; 1: 175.

30- Mostafa HM, El-Sewedy SM, Abdel-Tawab GA, El-Zoughby SM, El-Sharkaway A, Rashad M, Soliman MH and El-Kholy A. Studies on the effect of copper and mercury on some vitamin B6-catalyzed reactions kinetic. J Med Res Inst 1980; 1: 13.

31- El-Sewedy SM, Mostafa HM, Soffar AM and Abdel-Kader HM. Flourimetric determination of kynurenic acid xanthurenic acid in mouse liver homogenates. J Med Res Inst 1980; 1: 161.

32- Mostafa HM, Soffar AM, El-Sewedy SM and Abdel-Tawab GA. Effects of phenylamine, tyrosine, histidine and tryptophan on kynurenine hydrolyse and kynurenine aminotransferase of normal mouse liver. J Med Res Inst 1980; 1: 185.

33- El-Sewedy SM, El-Melegy S, Akhnoukh S, Sallam N and Abdel-Rafee A. In vivo effects of some antimonial and non-antimonial schistosomicidal drugs on liver -glucuronidase enzyme activity. Biochem Pharmacol 1980; 29:2925.

34- El-Sewedy SM, Mostafa HM, Soffar AM and Abdel-Rafee A. Effect of some tryptophan metabolites on the activity of B6-dependent kynurenine aminotransferase enzyme. ISTRY-80, Kyoto, August 4-7. 1980, Japan.

35- El-Sewedy SM, Soffar AM, Arafa A, El-Borno FA and El-Zoughby SM. Effect of some physiologic and pathologic factors on the activity of urinary alpha-naphthyl acetate esterases in bilharzial bladder cancer. The Fourth International Symposium on Prevention and Detection of Cancer. July, 26-31, London, 1980.

36- El-Sewedy SM and Zahran MA. Effect of some cytotoxic drugs on the activities of pancreatic ribonuclease and deoxyribonuclease. J Med Res Inst 1981; 2: 211.

37- El-Sewedy SM, Mostafa HM, Al-Bassiouni EA and Zahran MA. Effect of methansulphonate of hycanthone (Etrenol) on the activities of liver acid ribonuclease and deoxyribonuclease of normal and S. mansoni infected mice. Med Res Inst 1981; 2: 201.

38- El-Sewedy SM, Arafa A, Mostafa HM and El-Zoughby SM. Urinary alpha-naphthyl acetate esterases : A preliminary screening test for bladder cancer. Cancer Detection and Prevention 1981; 4: 455.

39- Aknoukh S, EL-Shazly N, Sallam N, El-Melegy S, El-Sewedy SM and Mostafa HM. In vivo effect of chloramphenicol and thiophenicol on some enzymes of normal mouse liver. Biochem Pharmacol 1982; 31: 55.

40- Mostafa HM, El-Sewedy SM, Al-Bassiouni EA and Abdel-Tawab GA. In vivo and in vitro studies on the effect of some phenothiazines and sulpiride on kynurenine metabolism. Biochem Pharmacol 1982; 31: 2227.

41- Mostafa HM, El-Sewedy SM, Al-Bassiouni EA and Abdel-Rafee and El-Sebae AH. Effect of fenvalerate on the activities of kynurenine metabolizing enzymes and acid ribonuclese of mouse liver. J Environ Sci Health 1982; Part B 17: 571.

42- El-Sewedy SM, Zahran MA, Zeidan MA, Mostafa MH and Al-Bassiouni EA. Effect and mechanism of action of methomyl and cypermethrin insecticides on kynurenine metabolizing enzymes of mouse liver. J Environ Sci Health 1982; Part B 17: 527.

43- Mostafa MH, Al-Bassiouni EA, El-Sewedy SM, Tawfic T and El-Sebae AH. Influence of pretreatment with various insecticides on the N-demethylation of dimethylnitrosamine. Environ Res 1983; 32: 57.

44- Omar AME, Farghaly AM, Hazzaa AAB, Eshba NH and El-Sewedy SM. Steroidal derivatives: Synthesis and in vitro anabolic alkylatig agents. Pharmazie 1983; 38: 445.

45- El-Sebaii AI, Omar AME, Habib NS, Aboulwafa OM, El-Sewedy SM and Bourdais J. Steroidal thiourea and thiazines derivatives: Synthesis and in vitro on bovine pancreatic ribonuclease activity. J Pharmacol Sci 1983; 72: 1205.

46- Mostafa MH, Al-Bassiouni EA, El-Sewedy SM, El-Zoughby SM, Ramadan M, Abdel-Tawab GA and El-Sebae AH. Effect of xenobiotics on kynurenine aminotransferase of mouse liver. J Environ Sci Health 1983; Part B 18: 393.

47- Mostafa MH, Al-Bassiouni EA, El-Sewedy SM, Akhnoukh S, Tawfic T and Abdel-Rafee. Hepatic microsomal enzymes in S. mansoni infected mice: I- Effect of duration of infection and lindan administration on dimethylnitrosamine demethylase and aniline hydroxylase. Environ Res 1984; 35: 154.

48- Mostafa MH, Al-Bassiouni EA, El-Sewedy SM, El-Meligy S, Abdel-Aziz T and Abdel-Rafee A. Hepatic enzymes in S. mansoni infected mice: II- Effect of duration of infection and lindan administration on aminopyrine demethylase and aniline hydroxylase. Environ Sci Health 1984; Part B 19: 193.

49- Abdel-Tawab GA, Mostafa MH, El-Sewedy SM, El-Zoughby SM, Agag AM and El-Sebae AH. Modification of kynurenine metabolism: I- Effect of insecticides. Cancer Detection and Prevention 1984; 5: 71.

50- Ali SF and El-Sewedy SM. Effect of gossypol on liver metabolic enzymes in male rats. Toxicol Lett 1984; 23: 299.

51- El-Habet AE, El-Sewedy SM, El-Sharaky A, Gaafar NK, Abdel-Rafee A and Hamouda F. Biochemical studies on bilharzial and non-bilharzial hyperoxaluria : Effect of pyridoxine and allopurinol treatment. Biochem Med Metab Biol 1987; 38: 1.

52- El-Habet AE, Abdel-Rahman SZ, El-Sewedy SM and Arfa A. Effect of urinary tract infection on alpha-naphthyl acetate esterase as a marker for bladder tumour grade. J Med Res Inst 1987; 8: 365.
53- Zahran MA, El-Sewedy SM, Abdel-Aal AN, Hashem EA and Galal SH. Biochemical studies on the effect of some schistosomicidal drugs on the production of bladder carcinogen xanthurenic acid. Bull Alex Fac Med 1988; 14: 17.

54- El-Toukhy MA, Ebied SA, Hassan AA and El-Sewedy SM. In vivo studies on the effect of some insecticides on the hepatic activity of L-tryptophan 2,3-dioxygenase and pyridoxal phosphokinase. J Environ Sci Health 1989; Part B 24; 265.

55- Hassan AA, El-Sewedy SM, Minatogawa Y and Kido R. Effects of some insecticides on several enzymes of tryptophan metabolism in rats. J Environ Sci Health 1990; Part B 25; 333.

56- Hassan AA, Minatogawa Y, El-Sewedy SM, and Kido R. In vitro effect of dimethoate on tryptophan pyrrolase. J Environ Sci Health 1991; Part B 26; 333.

57- Hassan AA, El-Khalili M, Abdel-Rahman SZ and El-Sewedy SM. Effect of gamma radiation on tryptophan metabolism in rat liver and kidney. Proceeding of the 7th meeting of International Study group of Tryptophan Research (ISTRY-1992), June 1992, Nagoya, Japan.

58- Zaghloul TI, Ibrahim NM, El-Sewedy SM and Helmi S. Utilization of Tomato-Processing waste by a genetically engineered Bacillus subtilis strain. Proceeding of the First Egyptian-Italian Symposium on Biotechnology, Assiut, Egypt, Nov. 21-23 1992.

59- El-Sewedy SM, El-Zoughby SM, El-Gazayerly IM, Aboul-Azm T and Hussein NG. Evaluation of some urinary enzymes and serum vitamin A in diagnosis of bilharzial and non-bilharzial bladder cancer. Med Sci Res 1993; 21: 63.

60- El-Khalili M, Helmy M, Hassan AA, Aboul-Azm T, El-Sewedy SM. Studies on urinary alpha-naphthyl acetate esterase isoenzymes in bladder cancer patients. Egypt J Med Sci 1993; 14: 195.

61- El-Toukhy MA, Hussein NG, Mahmoud WI, El-Khouly ZA, Saad AA and El-Sewedy SM. Evaluation of serum -glucuronidase and urinary aryl sulphatases A and B as biological markers in bladder cancer patients. Med Sci Res 1993; 21: 557.
62- El-Sharaky AS, El-Sewedy SM, El-Sayed MM and El-Shahawy IN. Effect of gossypol, apogossypol and gossypolone on fertility of male rats and in vitro sperm mobility. Qatar Univ Sci J 1993; 13 (2): 214-218.

63- El-Sharaky AS, El-Sewedy SM, El-Sayed MM and El-Shahawy IN. The effect of gossypol, gossypolone and apogossypol on the lipids of male rat serum and seminal fluid. Qatar Univ Sci J 1993; 14 (C): 32-38.

64- El-Sharaky AS, El-Sewedy SM, El-Sayed MM and El-Shahawy IN. Effect of gossypol, apogossypol and gossypolone on fatty acids pattern of lipid fractions in rat serum and seminal fluid. Qatar Univ Sci J 1993; 14 (C): 68-74

65- Hassan AA, Airoldi L, Abdel-Mohsen MA, Fanelli R, D’Incalci M and El-Sewedy SM. DNA damage, repair and detoxification in bladder carcinoma associated with schistosomiasis in Egyptian patients. The Seventh Medical Research Conference - The Third Italian - Egyptian Workshop (Environment and Health), 29-30 October 1994.

66- Abdel-Mohsen MA, Airoldi L, Hassan AA, Fanelli R, Aboul-Azm T and El-Sewedy SM. Urinary excretion of total N-Nitroso compounds, some volatile N-nitrosamines, nitrite and nitrate in bilharzial bladder cancer patients. The Seventh Medical Research Conference - The Third Italian - Egyptian Workshop (Environment and Health), October 1994.

67- El-Sharkaway AM, Abdel-Rahman SZ, Hassan AA, Gabr MH, El-Zoughby SM and El-Sewedy SM. Biochemical effects of some insecticides on the metabolic enzymes regulating glutathione metabolism. Bull Environ Contam Toxicol 1994; 52: 505.

68- Saad AA, Mohamedeen N, El-Toukhy MA, Hussein NG, Abdel-Wahab W, Mostafa A and El-Sewedy SM. Malnutrition diabetes and concomitant pancreatic changes (an experimental study). Egypt J Med Lab Sci 1994; 3 : 189.

69- El-Sewedy SM, El-Zoughby SM, Ebied SA And El-Sheikh EE. A study on the activity of UDP-glucuronyl transferase and -glucuronidase. in the kidney of S. mansoni infected mice treated with dimethyl N-nitrosamine. . The Seventh Medical Research Conference - The Third Italian - Egyptian Workshop (Environment and Health), 29-30 October 1994

70- El-Sewedy SM, Saad AA, Hussein NG, Hashem SA. The effect of Dimethylnitrosamine (DMN) on renal phenolsulphotransferase and Aryl sulphatase activities in S mansoni infected mice. . The Seventh Medical Research Conference - The Third Italian - Egyptian Workshop (Environment and Health), 29-30 October 1994

71- Youssef AI, El-Kady MH, Rashad MM, El-Toukhy MA and El-Sewedy SM. Effect of S. mansoni infection and dimethlnitrosamine (DMN) on some hepatic conjugating and deconjugating enzymes in male mice. . The Seventh Medical Research Conference - The Third Italian - Egyptian Workshop (Environment and Health), 29-30 October 1994

72- Abdel-Mohsen MA, Hassan AA, Magagnotti C, El-Sewedy SM and Airoldi L. Metabolic activiation of N-Nitroso compounds by bilharzial and non-bilharzial bladder tissues. The Eighth Medical Research Conference, The fourth Egyptian - Italian Workshop (Community and Health), 26-27 October 1996.

73- Alaa A, Elsayed M, El-Sewedy SM and Abdel-Rehim W. Effect of triclabendazol treatment on lipid peroxidase and erythrocyte glutathione reductase in acute and chronic human fascioliasis. The Eighth Medical Research Conference, The fourth Egyptian - Italian Workshop (Community and Health), 26-27 October 1996.

74- El-Sewedy SM, Mousa S, Soja C, Norberto P and El-Abd E. Mediators of cycosporine A (CSA) nephrotoxicity. The Eighth Medical Research Conference, The fourth Egyptian - Italian Workshop (Community and Health), 26-27 October 1996.
75- Hassan AM, Tagliabue G, Codegoni AM, D’Incalci, El-Sewedy SM and Airoldi L. Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: comparison with uninvolved tissues. Cancer Lett 1997; 121:19-23.

76- Abdel-Mohsen MA, Hassan AA, Magagnotti C, Airoldi L, Fanelli R, Aboul-Azm T and El-Sewedy SM. Studies on the aetiologic role of N-Nitroso compounds in bilharzia-associated and non-bilharzial bladder cancer in Egypt. “The International Conference on Infectious Diseases and Public Health - A Research and Clinical Up Date”, Conference Hall, Alexandria, Egypt, 17-20 October 1997.

77- Hassan AAM, Saleh RM, Girgis RS and El-Sewedy SM. Role of metabolizing enzymes in nitrosamines associated carcinogenesis during Schistosoma mansoni infection: Demethylase I and II. “The International Conference on Infectious Diseases and Public Health - A Research and Clinical Up Date”, Conference Hall, Alexandria, Egypt, 17-20 October 1997.

78- Hassan EA, Hassan AM, Hamdy HAM, Renganathan E, Aboul-Azm T and El-Sewedy SM. Glutathione-S-transferase Mu (GST Mu) isoenzyme as a possible biomarker in the development of urinary bladder carcinoma in schistosoma-infected patients. “The International Conference on Infectious Diseases and Public Health - A Research and Clinical Up Date”, Conference Hall, Alexandria, Egypt, 17-20 October 1997.

79- Abdel-Mohsen MA, Hassan AM, El-Sewedy SM, Abul-Azm T, Magagnotti C, Fanelli R and Airoldi L. Monitoring of N-nitroso compounds and their precursors in the urine of bladder cancer patients with or without Schistosoma haematobium infections. Int J Cancer. 1999; 82(6): 789-94.

80- Abdel Mohsen MA, Hassan AA, El-Sewedy SM, Aboul-Azm T, Magagnotti C, Fanelli R, Airoldi L. Human bladder cancer, schistosomiasis, N-nitroso compounds and their precursors. Int J Cancer. 2000; 88(4): 682-3.

81- Hassan AA, Amin GAM, Abdel Mohsen MA, Fadaly GA, El-Sewedy SM. Role of oxidative stress, GST-pi isoenzyme and P53 gene mutation in development of hepatocellular carcinoma in patients with chronic viral hepatitis C with and without Schistosomiasis. J Med Res Institute 2004; 25 (2): 152-178.

82- Hala El Adawi, Mohamed A. Abdel Mohsen, Dalia Yousef and El-Sewedy SM. Study on the effect of grape seed extract on hyperchloestrolemia: Prevention and treatment. International J Pharmacol 2006; 2 (6):593-600.


Supervision of Thesis
I- Ph.D. Thesis

1- Studies on -glucuronidase and esterases in schistosoma mansoni infected mice during treatment with non-antimonial anti-bilharzial drugs.
BY : Mona M Rashad

2- Studies on some biological markers in the diagnosis and prognosis of bladder cancer.
BY : Nabila G Hussien

3- Effect of gossypol and some of its derivatives on the fertility of male rats.
BY: Ibrahim Nagi El-Shahaway

4- Studies on the aetiology of bladder cancer: The effect of some insecticides in the formation of some endogenous bladder carcinogens from L-tryptophan in rats.
BY : Ashraf AM Hassan

5- Biochemical studies on urinary alpha-esterase isoenzymes in bilharzial and non-bilharzial bladder cancer.
BY : Mohamed M El-Khalili

6- Studies on the effect of bilharzial infection and dimethyl-nitrosamine on liver detoxifying enzymes of male mice.
BY : Amany I Youssef

7- Biochemical studies on some recently developed plasma volume expanders in rats.
BY : Nagwa M Assem

8- Effect of fasciola infection in humans, on serum and erythrocyte membrane lipids and their consequent (Ca2+/Mg2+) and (Na+/K+) adenosine triphosphatases in erythrocytes membranes.
BY : Wafaa M Abdel-Rehim

9- Evaluation of cyclic adenosine monophosphate (cAMP) and nuclear oestrogen receptors (ERn) in mammary tumour female rats after irradiation and hormonal therapy.
BY : Mohamed I Morsi

10- Effect of lead poisoning on some biochemical parameters in human and rat erythrocytes and the preventive effect of FE and vitamin C.
BY : Amal S. Mohamed

11- Biochemical study on the occupational exposure to vinyl chloride.
BY : Moustfa M Mahdy

12- Detection of some carcinogenic aromatic amines in water environment in West industrial region of Alex. and their effect on rats.
BY : Amany M El-Sekaily

13- Studies on the metabolism of N-Nitroso compounds in bladder cancer patients.
BY : Mohamed A Abdel-Mohsen

14- Glutathione-S-tranferase Mu (GST-Mu) isoenzyme in schistosoma-infected patients with and without bladder cancer.
BY : Hoda A Hamdy

15- Study of some biochemical and P53 proliferating factors in chronic viral hepatitis C patients with or without schistosomiasis.
BY : Rashad AA Thabet


II- M.Sc. Thesis

1- Studies on the effect of mercury ions on vitamin B6 catalyzed reaction kinetic in vitro.
BY : Awattef M El-Sharkawy

2- Biochemical studies on the excretion patterns of tryptophan metabolites especially the bladder carcinogenic metabolites - along the kynurenine - niacin pathway, in urine.
BY : Malika T Al-Sammarani

3- A study on the spontaneous urinary excretion of some carcinogenic tryptophan metabolites in Psoriasis
BY : Sherif Z Abdel-Rahman

4- Biochemical studies on the catabolic and anabolic activity of some Novel potential anticancer steroidal derivatives.
BY : Nagwa M Ibrahim

5- Studies on the non-specific esterases in bladder cancer patients.
BY : Fadl A El-Borno

6- The effect of some schistosomal drugs on the hepatic activity of 3-hydroxy kynurenine aminotransferase and pyridoxal phospho-kinase enzymes of mouse liver
BY : Amany I Youssef

7- Studies on serum and urinary ribonuclease activities in bilharzial and non-bilharzia; bladder cancer patients.
BY : Mohamed M El-Khalili

8- Study on adernocortical activity in premenstrual tension
BY : Seham A El-Sayed

9- Biochemical studies on red cell membrane in chronic renal failure.
BY : Hala I Mostafa

10- Effect of bilharzial hepatic fibrosis in patients, on lipids and calcium-magnesium, adenosine triphosphatase activity of erythrocyte membrane.
BY : Wafaa M Abdel-Rehim
11- The cAMP concentration in the rat myocardium with experimentally induced arrhythmia.
BY : Manal H Abdel-Aziz

12- Studies on the ribonuclease-inhibitor system and ribonucleic acid content during induction of liver tumour in rat with dimethyl- aminoazobenzene
BY : Mohamed A Abdel-Mohsen

13- The biochemical effects of some insecticides on the metabolic enzymes regulating glutathione metabolism.
BY : Moataz H Gabr

14- Evaluation of serum -glucuronidase and urinary arylsulphatase as biological markers in bladder cancer.
BY : Wafaa I Ismail

15- Biochemical study on ribonuclease isoenzymes of bladder cancer patients.
BY : Nada O Immam

16- Biochemical studies on blood platelets of chronic renal failure patients.
BY : Amany L Shenouda

17- Studies on hexose monophosphate (HMP) pathway in uremic red blood cells and its correlation with reduced glutathione (GSH) and ferrihaem.
BY : Samira Z Ibrahim

18- A study on the activities of UDP-glucuronyl transferase and -glucuronidase in the kidney of S. mansoni infected mice, treated with dimethylnitrosamine.
BY : Essam E El-Sheikh

19- The effect of dimethylnitrosamine on the activities of sulfo-transferase and arylsulfatase in S. mansoni infected mice.
BY : Seham A Hashem

20- The effect of dimethylnitrosamine on the activities of -glucuronidase, arylsulfatase and glutathione reductase of S. mansoni infected mince.
BY : Mohamed H El-Kady

21- Mediators of cyclosporine A (CSA) induced nephrotxicity.
BY : Eman A Ibrahim

22- Studies on the effect of dimethylnitrosamine on the activities of renal enzymes, glutathione reductase and glutathione transferase in S. mansoni infected mice.
BY : Samy M Abdel Rahman

23- Biotechnological studies on tomato processing waste.
BY : Nevin MY Ibrahim

24- Alteration in the capacity of kidney carcinogen metabolizing system in schistosoma mansoni infected mice: Demethylase I and II.
BY : Rasha M Saleh

25- A study on glucuronide, sulfate and glutathione enzyme systems in bladder cancer tissues.
BY : Rania Mohamed Fathy El-Lathy

26- Study of the gene expression level of P27 and murine double minute 2 (MDM2) in exfoliated cells from bladder cancer patients in Egypt.
BY : Magda El-Ebsheetty

27- Evaluation of c-erb B2 (oncogene) amplification and BRCA1 (tumour suppressor gene) mutation in exfoliated cells from bladder cancer patients in Egypt.
BY : Mona Saleh Tawfik

28- Expression of cyclo-oxygenase-2 in patients with hepatocellular carcinoma.
BY : Doaa Farghly Salman

29- Accumulation of hypoxia-inducible factor-1 (HIF-1) protein and cyclooxygenase-2 (COX-2) gene expression in human breast cancer tissue.
BY : Fatma Soliman


30- Detection of fragile histidine traid (FHT) promoter hypermethylation in breast cancer
BY : Mohamed Abdel Aal

31- Study on the hepatoprotection effect of oxothiazolidine against the toxicity of chlorpyrifos insecticide in mice
BY : Hewida Hassan El-Sayed Fadel

32- Study on the hepatoprotection effect of oxothiazolidine against the toxicity of chlorpyrifos insecticide in S. mansoni infected mice liver
BY : Fatima Amabd Ahmed

33- Study on the hepatoprotection effect of oxothiazolidine against S. mansoni induced cell injuries in mice
BY : Ahmed Badr El-Din

Experiences
Research Interest:
-Aetiologic factors of cancer in Egypt especially bladder cancer.
-Qualitative and quantitative analysis analysis of environmental pollutants.
-Mechanism of carcinogenesis.
-Tumour markers.
-Biochemical changes associated with parasitic infection.
No.of publications:
-81 scientific articles published in national and international journals.
-"Pharmacology of Kynurenine"a chapter in a Book entitled Quinolinic acid and kynurenine.
Teaching:
-Biochemistry :for post graduate students in preparatory courses in Institute of Postgraduate Studies and Research,Alexandria University.
-Cancer Chemistry: for post graduate students in preparatory course in Medical Research Institute,Alexandria University.

Others
Awards:
-Prize of Alexandria University for Research Activity 1980.
-The National Egyptian Prize in Biological Sciences,Academy of Research Sciences 1984.
-Prize of Alexandria University ,1997.
الأعمال الإنشائية التي لــها طــابـع الابــتكار والتميـــز:
أ- في مــيدان تخــصصه :
إنشاء توســـعات جــديدة بالــعيادة الخارجية لمســـتشــفى المعــهد والأقــسام العلــمية
ب- في مــيدان الجامعي والثقافي والاجتماعي والقومي:
مــتابعة إنشاء توســعات معــهد البــحــوث الطــبية بجــامعة الإسكندرية


Alexandria University Alexandria University