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Curriculum Vitae view

Personal Details
Name :    Madiha Mohamed Hassan Helmy
Department :    Biochemistry
Date of Birth :    1/1/1943
Country of Birth :    Egypt
Job :    Professor of Biochemistry
E-mail :    madihahelmy@yahoo.com

Affiliation
Professor of Biochemistry – Medical Research Institute – Alexandria University

Qualification

BSC Faculty of Science - Ain Shams University 1966
Diplome of microbiology - Cairo University 1968
Master Degree in microbiology - Cairo University 1974
PhD - Biological Chemistry - Cairo University 1985

Appointments
Chemist in Arab Drug Company Unit of Medical Plant Extraction. Sept. 1966 –Feb. 1976
Chemist in Blood & Plasma Fractionation Centre – Serum & Vaccine Organization March 1967
Head of Clotable Protein Department. Egyptian Organization Of Serum & Vaccine Oct. 1975
Appointed to Shatby Blood Bank to modify & prepare a centre of Clotable protein & platelets 1977 for 9 months
Head of Control of Blood Fractionation Center, Egyptian Organization of Serum & Vaccine 1983 – 1986
Specialist –Department of Biochemistry Medical Research Institute –Alex. University Dec. 1986
Lecture in Biochemistry MRI Dec. 1988
Assistant Professor MRI 1993
Professor of Biochemistry 1999
Head of Biochemistry Department 2001

Courses, Meetings & Conferences
Participated Conference:

1- 7th Conference of Medical Research Institute 29-30 Oct. 1994
Blood level of tissue plasminogen activator (t-PA). A delicate biochemical indicator of deep vein thrombosis (DVT).

2- International Egyptian / Italian co-operator 17-20 Oct. 1997
Changes in the defense against free radicals in the liver and plasma of the dog during hypoxia and/or Halothane anaesthesia.

3- The XIII Annual Conference Tanta University , Faculty Of Medicine 25-27 Mar. 1998
Effect of polluted fish intake on Interleukin 1,2 production, phagocytic function of mononuclear phagocytes and liver B- glucuronidase in rats.

4- The 15th Annual Conference for the Egyptian Society of Toxicology

“Environmental Pollutants and Drug Interaction”
Effect of selenium supplementation on the activities of glutathione metabolism enzymes in human HepG2 cell line.

5- The Future of Blood Transfusion Therapy And Components Industry in Egypt
The Future Research and Study Center. Cairo University 7-9 Apr. 2001
Virus inactivation and removal during production of albumin and gamma globulins.

6- The Egyptian Society Of Biochemistry and Molecular Biology 22-23 Apr. 2007-
Study on apoptosis and DNA base modification by oxidative stress in acute leukemia

7- The Egyptian Society of Biochemistry and Molecular Biology 29-30 Apr. 2008
The plasma level of selenium and tumor necrosis factor-α and achievers of glutathione peroxidases isoenzymes in colorectal cancer patients.


Attending Conference:

1- The International Symposium On Tropical Immunology.
The Egyptian Society Of Immunologists. 30-31 Oct. 1997

2- The 1st Conference in Biochemistry in Mansora Faculty of Medicine Mansora.
Mansora University. 14 Feb. 1998

3- The Laboratory and early detection of diseases 7-9 Mar. 1998



Courses:

Sharing in Biochemistry courses in MRI.
Sharing in the training course in Biochemistry Department.[ Some essential laboratory methods and principles for isolation and estimation of biochemical compounds of biological fluids.]

Publications
1- Plasma Lipids and Lipoprotein Pattern in Rheumatoid Disease.
D.A Hallous*; F. El Balasy*; Amira El Gerby*; Nayer Abou Rawash** and Madiha H. Helmy**.
* Dept. of Int. Med. Alexandria Faculty of Medicine, **Dept of Biochem. Med. Res. Inst. Alexandria University.
Bull. Alex. Fac. of Med. XXXVI (4) 739-744 (1990).

2- Comparison Between Osmotic and Loop Diuretics After Transurethral Resection of the Prostate on Plasma and Urine Sodium and Osmolality.
Salwa Sh. Shaarawy*; Nadya T. Kershah*, Magda Abo Ollo* and **Madiha H. Helmy.
* Dept. of Anaesthesia, Faculty of Medicine.
** Dept. of Biochemistry, Med. Res. Institute, Alexandria University.
The Egyptian Journal of Medical Sciences 11 (2) 464-473 (1990)

3- The Effect of Calcium Channel Blockers and Beta-adrenergic Blockers on Platelet Function and Fibrionolytic activity in Patients with Essential Hypertension.
Fathy El Belasy*, Ibtissam M Abdel Hamid*, Maged M Mikhail**, Madiha H. Helmy***.
* Dept. of Internal Medicine, Faculty of Medicine.
** Clinical Pathology, Faculty of Medicine.
*** Med. Res Inst. Alexandria University.
Bull. Alex. Fac. of Med. XXVII (6) 1991, 1327-1333


4- Correlation Between Lipid Peroxides and Lipoproteins in Different Types of Atherosclerosis.
*Madiha H. Helmy, *Nayer Abu-Rawahs; **Darwish A. Hallous and Mahmoud Aly M. El Mamlouk**.
* Dept. of Biochemistry Medical Res. Institute.
** Dept of Internal Medicine, Alexandria University.
Egypt J. Med Sci. 12 (2) 447-454 (1991)

5- Additives to dialysis solution which ameliorate its hemolytic effect.
*Nabil Mikhail, **Madiha H. Helmy and ***Mohamed Y. Hassan.
* Dept. of Physiology, ** Dept. of Biochemistry.
*** Dept of Medicine, Medical Res. Institute, Alexandria University.
Bull Alex. Fac. Med. XXVII (6) 1315-1320 (1991)

6- Study of Plasma Lipid Peroxides and Vitamin E in Rheumatoid Disease and Systemic Lupus Erythrocytosus.
*D.A. Hallous, *A. El-Gerbi, *R.A Kader, * I Abdel Hamid**, Madiha H. Helmy and **Nayer Abu- Rawash.
* Internal Med. Faculty of Medicine.
** Dept of Biochem. Med. Res. Ins, Alexandria University.
Egypt Rheumatologist 14 (1) 13-20 (1992).

7- Urinary Fibrin/firibonogen Degradation Products in Patients With Benign Urological Diseases and with Bilharzial Bladder Cancer.
*Madiha H. Helmy, *Michael AB, **El Toukhy MA, **Ebied S.A and **Saad AA.
* Dept. of Biochem. and Applied Med. Chem**, Medical Res. Inst. Alexandria University.
J of Med. Res. Inst. 13 (3) 181-190 (1992)

8- The Effect of Halothene on Protein Synthesis and Role of Amino Acids Perfusion in the Isolated Perfused Rat Liver.
*Magda Abo Ollo*, Mounir K Afifi**, *Nagwa A. Megahed, ***Madiha H. Helmy, *Farida A Mansour and Amal Wadie****.
* Dept. of Anaesthesia, **Dept of Biochem. *** and Dep of Physiology. Med. Res. Inst. and ** Faculty of Medicine.
J of Med. Res. Inst. 11 (2) 238-257 (1992)

9- Biochemical Studies on Erythrocytes Carbonic Anhydrase Enzyme in Asthmatics.
Soliman MH, Michael AB, Madiha H. Helmy Abd El Tawab S.M and Fayed HM.
Biochem. Dept of Med. Res. Inst.
J of Med. Res. Inst. 13 (4) 179-190 (1992)

10- Synergistic Action Between Infection with Schistosoma Mansoni and Treatment with Cortisone on B-glucuronidase Enzyme.
Samia A Ebid*, Mervat A El Toukhy*, Madiha H. Helmy**, Laila M Abu Samra*** and Suzanne M.F. El- Nassery***.
* Dept of Applied Med. Chem.
** Dept of Biochem. Med. Res. Inst.
*** Dept of Parasitology, Faculty of Medicine.
Bull Alex. Fac. Med. XXVIII (1) 231-236 (1992)

11- Skeletal muscle changes in Rheumatoid disease.
D.A. Hallous*, A El Gerbi*, R.A Kadder*, I Abdel Hamid*, MM. El-Bardawil**, N.M. Mohamedeen***, Madiha H Helmy****.
* Dept of Medicine, Physical Medicine, Faculty of Medicine.
** Dept of Pathology*** and Biochemistry**** Med. Res. Inst. Alexandria University.
Egypt Rheumatologist 14 (1) 21-34 (1992)

12- Studies on Urinary Alpha-Naphthyl Acetate Esterase Isoenzymes in Bladder Cancer Patient.
Mohamed El Khalili*, Madiha H. Helmy**, Ashraf A.M. Hassan*, Touson Abul Azm*** and Shehata M. El Sewedy*.
Dept of Applied Med. Chemistry*, Dept. of Biochem.** Medical Res. Inst.
Dept of Urology***, Fac. of Med, Alexandria University.
Egypt J. Med Sci 14 (1) 195-205 (1993)

13- Plasmid Profile of multiple resistant E. coli strains isolated from clinical specimens.
E. El Ghazzwai*, L. Hamdy**, O. Kader*, Madiha H. Helmy and Gamal El Saeaf*.
* Dept of Microbiology, ** Dept of Immunology, *** Dept of Biochemistry. Med. Res. Inst. Alexandria University.
Egypt J. Med Sci 14 (1) 127-141 (1993)

14- Urinary RNase isoenzymes: a possible marker in detection of bilharzial and non bilharzial bladder cancer.
S.M. El Sewedy*, Madiha H. Helmy**, N.O. Imam**, Aboulazm T. *** and I El-Gazayerly****.
** Dept. of Biochemi, Dept of Applied.
*** Dept. of Pathology Medical Research Inst.
**** Dept of Urology, Fac. of Med, Alexandria University.
Egypt J. Med Sci 14 (1) 125-130 (1993)

15- Molecular Weight Determination of Fasciola Antigen Specific for Diagnosis of Acute Fascioliasis.
M.M. Osman* and M.H. Helmy.
* Dept of Parasitology, ** Dept. of Biochemistry. Medical Research Institute, Alexandria University.
Journal of the Egyptian Society of Parasitology 24 (3): 471-478 (1994).
16- Effect of some enzyme activities of occupational exposure to vinyl chloride monomers for five consecutive years.
*Mona R., Mervat A. *El Toukhy, **Madiha H. Helmy, *Nabila H. and *Samia EB.
* Dept of Applied Medical Chemistry.
** Dept of Biochemistry, Medical Research Institute.
Med. Sci Res. (England ) (1994)11, 289-290.

17- Oxygen Toxicity of the Rat Lung in Protein Calorie Malnutrition.
*Madiha H. Helmy, **Magda Abo-Ollo, *Iman A, Sharaf and Nassamat M. Mohamedeen***.
* Dept of Biochemistry, Dept. of Anaethesia** and Dept of Pathology***, Medical Research Institute, Alexandria University.
Bull, Alex, Fac. Med. (USA) 31 (1): 176-189 (1995).

18- Evaluation of Fasciola excretory-Secretory (E/S) product in diagnosis of acute human fasciolasis by IgM Elisa.
M.M. Osman*, A.Y. Shehab*, S.A. El Masry**. M.H. Helmy*** and H.F. Farag*.
* Dept of Parasitology Medical Research Institute.
** Dept of Tropical Health, High Institute of Public Health.
*** Dept of Biochemistry Medical Research Institute.
Trop. Med. Parasitol 46 (2): 115-118, 1995.

19- Studies of Human Fasciolosis in Egypt: Some serum lipid parameters before and after treatment.
M.M. Osman*, M.H. Helmy** and M.A. Megehed**.
* Dept of Parasitology*, Dept of Biochemistry** Medical Research Institute, Alexandria University.
Journal of the Egyptian Society of Parasitology (1995), 25 (3): 769-772.

20- Legionella Pneumophilia Antibodies in Dialysed Uraemic Patients
Salah El Banawy*, Fatma Gamil**, Eglal El Sherbini, Madiha H. Helmy***, Nagwa Assem***, and Nader Mowafy*.
* Dept of Internal Medicine.
** Dept of Microbiology.
*** Dept of Biochemistry. Medical Research Institute, Alexandria University.
Bull. of High Institute of Public Health 25 (1): 64-71 (1995).

21.a- Biochemical Studies on Some Recently Developed Plasma Volume Expanders In Rats. Part 1:
S.M. Dawoud Ph.D, M.H. Helmy Ph.D., N. Assem M.Sc., Y. Gabr Ph.D., A. El-Habet Ph.D., S.M. El-Sewedy Ph. D*.
Departments of Biochemistry and Applied Medical Chemistry*, Medical Research Institute, Alexandria University.
Bull Alex Fac. Med. XXXI (1) 96-103 (1995).

21.b- Biochemical Studies on Some Recently Developed Plasma Volume Expanders In Rats. Part 2:
M.H. Helmy Ph.D., S.M. Dawoud Ph.D., N. Assem M.Sc., Y. Gabr Ph.D., A. El Habet Ph.D., S.M. El Sewedy Ph.D.*
Departments of Biochemistry and Applied Medical Chemistry*, Medical Research Institute, Alexandria University.
Bull Alex Fac. Med. XXXII (2) 154-158 (1996).

22- Blood Level of Tissue Plasminogen Activator (t. PA). A Delicate Biochemical Indicator of Deep Vein Thrombosis (D.V.T).
*Madiha H. Helmy, **N.A. Sadek, ***N.G Hussein, ****N.A Abdel Moneium, A. Abed Azim, M.E. Salem.
*Dept. of Biocehmistry, ** Dept. of Heamatology, ***Dept. of Applied Medical Chemistry, ****Dept. of Radiation Sciences. Medical Research Institute.
Dept. of Surgery. Fac. of Medicine Alexandria University.
J Med Res. Inst. 16 (1) 120-124 (1995).

23- Changes in Surfactant Protein of the Lung Following Oxygen Toxicity in Protein Malnourished Rats.
*M.M. Abo-Ollo and **Madiha H. Helmy.
*Dept. of Anaethesia, **Dept. of Biochemistry Medical Research Institute. Alexandria University.
Med. Sci. Res. (England) (1997) 25: 35-38.

24- Changes in the Defense Against Free Radicals in the Liver and Plasma of the Dog During Hypoxia and/or Halothane Anaesthesia.
E.A. El. Bassiouni*, M.M. Abo-Ollo**, M.H. Helmy*** S. Ismail*, MIA Ramadan**.
* Dept. of Pharmacology, **Dept. of Anaesthesia, *** Dept of Biochemistry, Medical Research Institute, Alexandria University.
Toxicology 128: 25-34 (1998)
Represented in the International conference on 10th Sept. 1997.

25- The clinical value of serum lactate dehydrogenase, ceruloplasmin, cathepsin-D and lipid-bound sialic acid in monitoring patients with malignant lymphomas.
*Madiha H. Helmy, Nadia A. Abd El Moneim**, Moustafa MA Abd El Baki***, and Safinaz M. El Zoghby****.
*Dept. of Biochemistry, **Dept of Radiation sciences, Dept. of Surgery and Dept. of Applied Medical Chemistry, Medical Research Institute, Alexandria University.
Medical Science Research (England) 26: 613-617. (1998)



26- Some Biochemical Parameters of Bone Turn-over in Diabetes Millitus.
*Hallous DA, ** Madiha H. Helmy, * Zohairy MA, and Tadrous A*.
*Dept. of Internal Medicine, Faculty of Medicine.
** Dept of Biochemistry-Medical Research Institute.
J of the Med. Res. Institute. 19 (3): 23-33, (1998).

27- Evaluation of Vaccination Trial Against Experimental Fascioliasis with a Purified Fasciola Gigantica Antigen.
*Madiha H. Helmy, **Abdel Ghany E Masry, ** Safaa M.M. Eassa, ** Sanaa A El Masry, ** Ebtissam Ali Omar.
*Dept. of Biochemistry Medical Research Institute.
** Dep. of Tropical Health, High Institute of Public Health, Alexandria University.
J of the Egyptian Biochemical Society 16 (2) 189-198 (1998).

28- Some Biochemical Studies on Erythrocytes Carbonic Anhydrase Isoenzymes and Some Metals in Patients with Renal Failure.
*Madiha H. Helmy, *Soraya M. Dawoud, Mohamed ** Nader Mowafy, *** Y. Ismail, * H.M. Fayed and ****A.M Soffar.
Dept. of Biochemistry, ** Kidney Unit, *** Clinical pathology Medical Research Institute, Alexandria University, **** Faculty of Medicine, Tanta University.
J of the Egyptian Biochemical Society 16 (2) 177-187 (1998)

29- Enternal Feeding in Critically ill patients.
* M. Naser El Deen, Madiha H. Helmy**, N. Abd El Rehim El Sayed***, M Abd El Rassoul*.
*Dept of Critical Medicine, Faculty of Medicine.
** Dept of Biochemistry Medical Research Institute.
*** Dept of Nutrition, High Institute of Public Health, Alexandria University.
J of the Med. Res. Institute. 19 (1): 196-208, (1998).

30- Effect of Polluted Fish Intake on Interleukin 1,2 production, phagocytic function of Mononuclear phagocyte and liver B-glucourodinase in rats.
Aziza A. Saad*, Shehata M. El Sewedy*, Madiha H. Helmy**, Nagwa M. Assem**, Soheir R. Demian*** Abu Seif H,**** and Amany MEL Sikaily*****.
*Dept. of Applied Medical Chemistry**, Biochemistry, ***Immunology and Pathology****, Medical Research Institute. Alexandria University and National Institute of Occanography and Fishers***** Alexandria University.
J. Med. Res. Inst 19 (2) 126-141 (1998)

31- Effect of Selenium supplementation on the activities of glutathione metabolizing enzymes in human hepatoma HepG2 cell line.
*Madiha H. Helmy, ** Saad S. Ismail, * Hassan Fayed, and **Emad A. El Bassiouni.
Dept. of Biochemistry, and **Pharmacology Medical Research Institute, Alexandria University.
*Toxicology 144, 57-61 (2000)

32- Serum Proteins and Glycoproteins in Acute Fascioliasis Before and After Triclabendazole Treatment.
*Madiha H. Helmy**, Mervat Osman, ***Saad Sedki, * Hassan Fayed and **** Osama A. Abbas.
*Dept of Biochemistry, **Parasitology and ***Pharmacology. Medical Research Institute, Alexandria University.
****Dept of Physiology, Faculty of Education Suez Canal University.
J Med. Res. Inst. 23 (3) 70-79 (2002)

33- Antioxidants as Adjuvant Therapy in Rheumatoid Disease.
*Mona Helmy, **Mohamed Shohayed, ***Madiha Helmy and ** Emad A. El Bassiouni.
*Unit of Rheumatology, Faculty of Medicine Dept of **Pharmacology and ***Biochemistry Medical Research Institute. Alexandria University.
Arzneim-Forsch/ Drug Res. 51 (1), 284-292 (2001)

34- Relation Between Circulating Total and Ionized Calcium and Magnesium in Yemeni Patients on Maintenance Haemodialysis.
* Hassan Fayed, *Madiha Helmy, **Safinaz El Zoghby, *** Abdallah A Gonaid and ***Mahmoud A. Ogaili.
*Dept. of Biochemistry and **Applied Medical Chemistry Medical Research Institute, Alexandria University, *** Dept of Internal Medicine, Faculty of Medicine, Sana'a University.
J Med. Res. Inst. 23 (2) 132-138 (2002)

35- Nitric Oxide generation by peripheral blood cells in chronic renal failure.
*H.M. Fayed, *M.A Kamel, **M.M. Sultan, ***M.N. Mowafy *M.H. Helmy and **** S.M. El-Zoghby.
*Dept of Biochemistry, **Haematology, *** Internal medicine and **** Applied Medical Chemistry, Medical Research Institute, Alexandria University.
Br. J of Biomedical Science 59 (1) 24-29 (2002)

36- Purification and Quantitation of Insulin Degrading Enzymes, their Activators and Inhibitors From Human Erythrocytes of Types 1 and 2 Diabetic Patients.
*Madiha H. Helmy, *Hassan M. Fayed and **Ana Abo Raya.
*Dept of Biochemistry, **Internal Medicine, Faculty of Medicine, Alexandria University, Medical Research Institute.
J. Med. Res. Inst. 23 (4) (2002)

37- Development of an Improved Method for Production of Antiscorpin F (ab\)2 Fragment of IgG with High Yield and Potancy.
*Salwa S. Seddik, *Soheir Wanas, *Awatef Shehata, *Shafika Fawaz and **Madiha Helmy.
*Antisera Plant, Egyptian organization for Biological products and vaccines (VACSERA) Dept. Medical Biochemistry, Medical Research Institute, Alexandria University.
J. of Natural Toxins, 11 (2) 123-132 (2002).

38- Cross Neutralization of Some Dangerous Snake Venoms of Africa and Middle East by the VACSERA Polyvalent.
*Salwa S. Seddik, *Soheir Wanas, **Madiha H. Helmy and *Mohamed Hashem.
*Antisera Plant, Egyptian Organization for Biological Products and Vaccines (VACSERA) **Dept. of Biochemistry, Medical Research Institute, Alexandria University.
J. Natural Toxins 11 (4) 2002.

39- The improved purification and yield of the Egyptian snak cerastes antitoxin by the use of caprylic acid.
*Salwa S. Seddik, ** Madiha H. Helmy.
*Antisera Plant, Egyptian Organization for Biological Products and Vaccines (VACSERA) Dept. Biochemistry, Medical Research Institute, Alexandria University.
J. of Natural Toxins, 11 (4) 2002

40. Molecular and immunological characterization of Fasciola Species.
*Amal F. Allam, El Sayed I El-Agamy** and Madiha H. Helmy***.
*Parasitology Dept. Medical Research Institute.
**Dairy Science Dept. Faculty of Agriculture and ***Biochemistry Dept. Medical Research Institute.
British journal of Biomedical Science. 59 (4) 1-5; 2000.


40- Molecular and immunological characterization of Fasciola Species.
Amal F. Allam*, El Sayed I El-Agamy** and Madiha H. Helmy.
Parasitology dept.* Medical research institute. Dairy Science Dept**.
Faculty of Agriculture and Biochemistry Dept. Medical Research Institute Alexandria University.
British journal of Biomedical Science. 59 (4): 1-5; 2000.

41- Effects of Bacillus thuringiensis toxin on hepatic lipid peroxidation and free radical scavengers in rats given alpha-tocopherol or acetylsalicylate.
Nadia Z. Shaban*, Madiha H. Helmy, Mohamed AR. El-Kersh*, Bothaina F. Mahmoud*.
Biochemistry Dept. Faculty of Science*. Alexandria University.
Biochemistry Dept. Medical Research Institute. Alexandria University. Egypt.
Comparative biochemistry and physiology part C: Toxicology and pharmacology: 135: 405-414; (2003).



42- In vitro effect of low concentration of Oltipraz on the antioxidant defence of mouse hepatocytes and schistosoma mansoni worms.
E.A. El Bassiouni, M.H. Helmy, M.A Abdel Hamid, M.A. Shohayeb, and S.S. Ismail. Depts. Of pharmacology, Biochemistry.
Medical research Institute. Alexandria University and Dept of pharmacology Faculty of Medicine Tanta University. Egypt.
Br. J of Biomedical Science 61 (1): 1-7(2004).

43- Embryopathy in experimental diabetic gestation assessment of PGE2 level, gene expression of cyclooxygenases and apoptosis.
E.A. El Bassiouni, M.H.Helmy, N-Abou Rawash, S.M. El-Zoghaby, M. Abd El-Nabi kamel and A.N. Abou Raya.
Depart of Pharmacology, Biochemistry and Applied medical Chemistry, Medical Research Institute and Dept. of Internal Medicine. Faculty of Medicine. Alexandria University Egypt,
Br. J of Biomedical Science, 2005; 62(4); 161-165.

44- Relationship between level of circulating modified LDL and the extent of coronary artery disease in type 2 diabetic patients.
EA. El Bassiouni, M.H. Helmy, S.M. El-Zoghby, MA. El -Nabi and R.M. Hosny Depts. Of Pharmacology, Biochemistry and Internal Medicine. Medical Research Institute. Alex. University Egypt.
Br J of Biomedical Science 64(3) 109-116 (2007).

45- Modulatijon of the antioxidant defence in different developmental stages of schistosoma mansoni by praziquantel and artemether.
EA El Bassiouni, M.H. Helmy, E.I. Saad, M.A. ElNabi Kamel, E.Abdel Meguid and H.S.E. Hussein.
Medical research institute and faculty of pharmacy. Alex university. Egypt.
Br. J of biomedical science 64 (4) 145-151 (2007).

46. The status of antioxidant defenses in glucose -6 phosphate dehydrogenase deficient patients. The role of antioxidants to ameliorate hemolytic crisis.
Safinaz El-zoghby*, Madiha H. Helmy. Amal M. Ghanem**. Mervat Y Hanafi, Maher Abd El-Nabi Kamel and Amal Ali El-Sayed.
Depts of Applied Medical Chemistry*, Biochemistry and Haematology**. Medical Research Institute. Alex. University. Egypt
J. of Biochemistry and Molecular Biology 25 (2): 114-133 (2007).
47. The levels of vascular endothelial growth factor-A and placental growth factor-2 in embryopathy associated with experimental diabetic gestation.
Salim MD, Al-Matubsi HY, El-Sharaky AS, Kamel MA, Oriquat GA, Helmy MH, El-Bassiouni EA
GROWTH FACTORS 2009; 27(1):32-9



Supervision of Thesis
Master Degree:

1- Biochemical study on ribonuclease iso-enzymes of bladder cancer patients. 1992

2-Studies on the value of fasciola excretory- secretory products as antigens in the immunodiagnosis of acute human infection. 1993

3-Biochemical study on tissue plasminogen activator in blood of patients with deep vein thrombosis of lower limbs. 1994

4- Cartilage oligomeric matrix protein in osteoarthrosis. 1995

5-Evaluation of fibronectin, carcinoembryonic antigen and alkaline phosphatase in biologic behaviour of breast cancer. 1997

6-The clinical value of serum lactate dehydrogenase, ceruloplasmin, cathepsin D, and lipid- bound sialic acid in monitoring patients with malignant lymphomas. 1997

7-Enternal feeding in critically ill patients. 1997

8- Study of some parameters of bone turn- over in diabetes mellitus. 1998

9- A studying on the blood level of nitric oxide and nitric oxide synthase activity in patients with chronic renal failure. 2000

10- Measurement of plasma 8-iso-PGF2α level as a marker of oxidative stress in type 2- diabetic patients with cardiovascular complications. 2001

11- Relation between circulating total and ionized calcium and magnesium in Yemeni patients on maintenance haemodialysis. 2001

12- Study on hepatic glutathione and related enzymes in schistosoma mansoni infected mice. 2003

13- The role of adenosine metabolizing enzymes 5′- nucleotidase and adenosine deaminase in hypertensive patients. 2005

14- Serum adenosine deaminase activity and its isoenzyme pattern as a marker for monitoring disease activity in systemic lupus erythematosus patients. 2005

15- Urokinase plasminogen activator level in primary breast cancer : relation to metastases. 2005

16- Modulation of the antioxidant defenses in different developmental stages of Schistosoma Mansoni by praziquantel and Artemether. 2005

17- Prognostic significance of urokinase plasminogen activator inhibitor-1 in breast cancer and its correlation with different prognostic factors. 2007

18- Alteration of plasma thrombomodulin level prior to and after plateletpheresis: relation to smoking induced oxidant status and changes in plasma lipid. 2007

19- Effect of selenium level on the activities of glutathione peroxidase isoenzymes and TNF-α in colorectal cancer patients. 2008

20- Monitoring chromium levels and antioxidant enzyme activities in blood, plasma and urine of workers in the petrochemical industry. 2008

21- The relationship between the level of advanced glycation end products and extent of cardiovascular disease in type-2 diabetic patients. At end


PhD Degree

1- Biochemical studies on urinary α esterase isoenzymes in bilharzial and non-bilharzial bladder cancer patients. 1992

2- Biochemical studies on some recently developed plasma volume expanders in rats.
1992

3- Plasmid profile of multiple resistant E. coli strain isolated from clinical specimens.
1993

4- A study of cartilage oligomeric matrix protein { COMP} as a new marker of cartilage turn over in rheumatoid. 1996


5- Detection of circulating fasciola antigens (CFA) and specific antibodies in the sera of infected patients. A chronological study. 1997

66- A study of cartilage oligomeric matrix protein { COMP} as a new marker of cartilage turn over in rheumatoid. 1996
- Evaluation of vaccination trial against experimental fasciolosis with a purified fasciola gigantica antigen. 1997


7- Effect of Dipel on the lipid peroxidation and some related enzymes. 2002

8- A comparative study on the effect of oltipraze on glutathione metabolism in cultured mouse hepatocytes and schistosoma mansoni. 2002

9- A study on biochemical changes in embryos of rats exposed to diabetic environment.
2003

10- Relationship between the level of circulating modified LDL and the extent of coronary artery disease in type-2 diabetic patients. 2005


11 - The status of antioxidant defence in glucose-6-phosphate dehydrogenase deficient patients The role of antioxidants to ameliorate hemolytic crisis. 2006

12 - Cellular redox status in relation to Apoptosis in Leukemic patients. 2007

13- Study on apoptosis and DNA base modification by oxidative stress in acute leukemia . 2007


14- Study on apoptosis and DNA base modification by oxidative stress in systemic lupus
Erythematosus patients. At end

Experiences
• Purification and preparation of blood fractionation prduct such as albumin, globulins, Clotable proteins : anti-hemophilic globulin, Christmus factor,and platlets.
• All techniques of chromatography and electrophoresis.
• Tissue culture techniques.

Others
Scientific Activities :

Training fellowship in “Centre National de Transfusion Sanguine” in Paris for 9 months from Oct. 1972 – Jun. 1973 in the field of “ Blood Fractionation”.
Training fellowship in “Centre National de Transfusion Sanguine” Paris for one year in the field of “ Clotable Protein Preparation”.

Training course in LKB Company on Chromatography Techniques in Athena “ Greece”.
Fellowship in University of Tor Vergata “Rome” for 6 months from June 95- Nov. 1995.

Training on Tissue Culture > Performing the experimental parts of the project:
Therapeutic Aproaches for Treatment of Schistosomasis & other Parasite infection by means of drug producing free radicals.

Project with the Italian { Italian / Egyptian co-operation } Effect of Oltipraz on hepatoma cells.
performing experimental parts in the University of Torvergata “Roma” for 2 months.

Development of an method for production of antiscorpin F(ab)2 fragment of IgG with high yield and potency. With {VACSERA}.

Cross neutralization of some dangerous snake venoms of Africa and Middle East by {VACSERA }.


Alexandria University Alexandria University