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Curriculum Vitae view

Personal Details
Name :    Aziza Abd El_Azim Ibrahim Saad
Department :    Applied Medical Chemistry
Date of Birth :    
Country of Birth :    
Job :    Professor of Medical Biochemistry
E-mail :    aziza.a.saad@gmail.com

Affiliation
Applied Medical Chemistry Department
Medical Research Institute
Alexandria University

Qualification
B.Sc (chemistry- Zoology): Faculty of Science, Alexandria University, 1963.
M.Sc (Biochemistry): Faculty of Science Alexandria University, 1967.
Ph.D. (Biochemistry): Faculty of Science, Cairo University, 1974.

Appointments
• 14/3/65 – 4/12/72: Demonstrator in Applied Medical Chemistry Department.
• 5/12/72 – 23/9/74: Assistant lecture in Applied Medical Chemistry Department.
• 24/4/72 – 5/11/79: Lecture in Applied Medical Chemistry department.
• 6/11/79 – 1/7/85: Assistant Professor in Applied Medical Chemistry Department.
• 1/7/85 – present: Professor of Medical Biochemistry in Applied Medical Chemistry Department.
• 1988 – 1994 : Head of Applied Medical Chemistry Department.

Courses, Meetings & Conferences
Courses:
- Practical and Clinical Enzymology.
- Molicular Endocrinology.
- Mitabolic interrelationship.
- Cancer Chemisitry.

Conferences:
- Conferences of medicine and law society.
- The annual confrences of Medical Research Institute.

Publications
1. G.A. Abdel-Tawab, E. Khalil, M.H. Abdel-Daim, S.M. El-Zoghby, F.S. Kelada and A.A Saad: Studies on the aetiology of bilharzoa carcinoma of the urinary bladder. IX international. Cancer Congress, Tokyo, October 23-29,Abstract of paper,p.612 (1966).
2. G.A. Abdel-Tawab, S.M. El-Zoghby, Y.M. Abdel-Samie,A.Zaki and A.A Saad: Studies on the aetiology of bilharzial carcinoma of the urinary bladder. VI- β-Glucuronidase in urine. Int. J. Cancer, 1, 383 (1966).
3. A.H Mousa, A.F. Abdek-Wahab, W.Mousa, G.A Abdel-Tawab, A.A Saad and N.L Kelada: Tryptophan metabolism in hepatosplenic bilharziasis. Trans. Roy. Soc. Trop. Med. Hyg., 61,640 (1967).
4. G.A Abdel-Tawab, A.A Saad, E.K. Ibrahim, M.H Mostafa , A.H. Mousa, A.F Abdel-Wahab and W.Mousa: Tryptophane metabolism in some helminthiasis, Trans, Roy. Soc. Trop. Med. Hyg., 62, 243 (1968).
5. S.M El-Zoghby, G.A Abdel-Tawab, A.A Saad and G.E Moursi: Contraceptive steroids and endogenous production of bladder carcinognes: Approach to adverse drug reactions, Second International Symposium on Cancer Detection and Prevention, Bologna, Italy, April 9-2 (1973).
6. A.A Saad, G.A Abdel-Tawab, S.M El-Zoghby, M.H Mostafa and G.E Moursi: Relationship between pyridoxal phosphate and some synthetic oestrogens in their effect on kynurenine hydrolase and kynurenine aminotransferase enzymes of normal mouse liver. Biochem. Pharmacol., 23,999 (1974).
7. G.A Abdel-Tawab, S.M El-Zoghby and A.A Saad: Relationship between pyridoxal phosphate and some synthetic oestrogens gonadotrophin and thyroxine in their effect on kynurenine aminotransferase enzymes of normal mouse liver : Acta Vitam. Enzymol., 29, 329 (1975).
8. S.M El-Zoghby, S.M. El-Sewedy. A.A. Saad, M.H. Mustafa. S.M. Ebied and G.A. Abdel-Tawab: In vitro trials to counteract the inhibitory effect of β-oestradiol and ethynyloestradiol on the B¬6-dependent kynurenine aminotrasferase enzyme: Biochem. Pharmacol., 25, 2411 (1976).
9. M. H. Mostafa, S.M. El-Sewedy, S.M. El-Zohby. A. A. Saad, H. El-Kabarity and Z. Rakonczay: In vitro effect of some naturally secreted hormones on tyrosine hydroxylase activity of beef adrenal medulla: Agressologie, 18 (5), 253 (1977).
10. A.A. Saad. H.F. Farag. S.M. El-Zoghby. M. H. Mostafa and L. H. Girgis: β-Glucuronidase activity in liver and spleen homogenates of mice experimentally ifectedwith Schistosoma mansoni. Acta Vitam. Enzymol., 31, 179(1977).
11. A.A. Saad, S. M. El-Zoghby, H. F. Farag, S. M. El-Sewedy. L. H. Girgis and M. Moghazy: Biochemical studies on β-glucuronidase enzyme in the urinary bladder of normal and Schistosoma mansoni infected mice treated wit hycanthone, Acta Vitam. Enzym., 31, 183 (1977).
12. A.A. Saad, S. M. El-Zoghby, H. F. Farag, S. M. El-Sewedy. L. H. Girgis and M. Moghazy: Biochemical Studies on β-glucuronidase enzyme in liver and spleen homogenates of normal and Schistosoma mansoni infected mice treated with hycanthone: Biochem. Pharmacol., 27,473(1978).
13. S.M.EL-Sewedy, M.H. Mostafa , A.A Saad.S.M.EL-Zoghby .H.EL-Kabarity , N.EL-Dardiry , S.EL-Sahwi, L.Kira and M.Rizk : The effect of naturally secreted hormones on the activity of ribronuclease enzyme : Tanta Med .J., 6 (1) , 237 ( 1978)
14. EL – Zoghby .S.M ., EL –Sewedy , S.M ., Saad , A.A ., Mostafa . M.H ., EL-Kholy , Z.A ., EL –Touky , M.A ., Abdel –Tawab , G.A : In vitro studies on the effect of metal ions , EDTA and their mixture on kynurenine aminotransferase and kynurenine hydrolase : Acta Vitam . enzyme .32, 145 (1978 ) .
15. S.M . EL –Zoghby , Z.A .EL-Kholy , A.A.Saad , M.H . Mostafa , G.A . Abdel –Tawab , N.EL-Dardiry , H.EL-Kabarity , A . Abdel –Rafae : The effect of environment on tryptophane metabolism “via Kynurenine “ in oral contraceptives users : Acta vitam . Enzymol , 32 , 167 (1978 ) .
16. A.A . Saad , S.M . EL –Zoghby , S.M . El –Sewedy , Z.A. EL-Kholy , N.EL –Dardiry , H.EL-Kabarity and M . Rizk : Biochemical studies on the effect of duration of oral contraceptive administration on B glucuronidase enzyme activity in serum and vaginal fluid : Bull . Alex . Facul. Med . Vol . XV (4 ) , 615 (1979 ) .
17. Z.A . EL Kholy , S. M . EL – Zoghby , H.F . Farag , M.A . EL –Toukhy. A.A Saad , and G.A . Abdel –Tawab : Influence of Astiban on liver , spleen , kidney and urinary bladder B -Glucuronidase of normal and Schistosoma mansoni infected mice : Biochem . Pharmacol ., 28 . 3171 (1979) .
18. N. EL – Dardiry , H. EL –Kabarity , S . EL –Sahawi , A.EL –Fazzari , L. Kira , M.Rizk , S.M . EL –Sewedy . M.H . Mostafa , G. Abdel –Aal and A. A . Saad : Biochemical and cytochemical changes of alpha – esterases activity in long –term oral contraceptive users : Bull . Alex . Facul. Med . Vol. XVL (2) (1980 ) .
19. N.EL –Dardiry , H. El –Kabarity , S. Marrei , S.El –Sahwl , L, Kira and M. Rizk , S.M . El –Sewedy , M.H . Mostafa , A.A . Saad and S.M . EL –Zoghby : effect of prolonged use of oral contraceptive pills on the activity of serum and vaginal ribonuclease : Bull. Alex. Facual. Med. Vol.XVI(2) (1980).
20. N.EL-Dardiry, A.Fazary, M.Rizk, A.A Saad, S.M. El-Zoghby and Z.A El-Kholy: Biochemical studies on the effect of duration of intra-uterine contraceptive device Lippes loop on β-glucuronidase enzyme activity in vaginal fluid and serum: Bull. Alex. Facual. Med. Vol.XVI(3),489 (1980).
21. S.M El-Zoghby, S.A Ebied, Z.A El-Kholy, A.A Saad, G.A Abdel-Tawab, N.A Hammouda and Y.A El-Gohary: Effect of Oxamniquineon liver, spleen, kidney and bladder β- glucuronidase in normal and Schistosoma mansoni infected mice : Biochem. Pharmacol, 29. 429 (1980).
22. Z.A El-Kholy, A.A Saad, S.M El-Zoghby , N El-Dardiry, S Marie, H El-Kabarity and M Rizk: β- glucuronidase enzyme activity in endometrium and vaginal fluid of copper 7₂₀₀ IUD users two and three years after its insertion: J.Med.Resear.Instit.Vol.1, 55(1983).
23. M.A El-Toukhy, A.A Saad, H Farag, S.Ebeid, L Abo-Basha and A EL-Magdoub: The effect of fasciolicidal drug: Bithional on the B₆-dependent kynurenine hydrolase and kynurenine aminotransferase in the liver homogenates of normal and Fasciola gigantic infected rabbits : Bull.High Inst.Pub.Health.Vol.XIII(5), (1983).
24. Z.A EL-Kholy, M.A El-Toukhy, S.A Ebeid, A.A Saad and S.M El-Zoghby: Periodontits and β- glucuronidase activity in Egyptian Patients: J.Med.Res.Inst.1, 43 (1983).
25. Z.A El-Kholy, M.A El-Toukhy , S.A Ebeid , A.A Saad, and S.M El-Zoghby: Oral cancer and β- glucuronidase activity: J.Med.Reseat.Inst.vol.1, 97 (1983).
26. A.A Saad, N.Abu-Rawash, M.M Rashad, Z.A El-Kholy: The effect of Trichomonas infection on immunoglobulin and β-glucuronidase enzyme in long-term pill users: Bull.High Inst.Pub.Heal.Vol.XTV(4),(1984).
27. A.A Saad, S.W Skander, A Dessuki and M.E Salem: β- glucuronidase: A diagnostics and prognostic method in evaluation of schistosmiasis of the liver: Bull. Alex. Facual. Med. Vol.XX(4) (1984).
28. A.A Saad, Z.A El-Kholy, E.M Hassan, M.E Salem, M.A El-Tokhy , S.A Ebeid, L.M Abou-Basha and A. Dessuki: Serum immunoglobulin levels and β-glucuronidase activity in hepatosplenic bilharzias: Bull. High Instit.Pub Health.Vol.XIV(2),(1984).
29. Z.A. El-Kholy. M.A. El-Tohky. A.A. Saad. S.A. Ebied, F. Hamoud and 1.A. Moghazi: The hydrolyic power of urinary β-glucuronidase(s) in some bilharzial urinary tract diseases: J. Med. Resear., 5, 163(1984).
30. A.A. Saad. H.F. Farag. M Ragab. M.E. El-Toukhy. Z.A. El-Kholy. M.M. Rashad, L.M. Abou-Basha and L. Ziada: β-glucuronidase activity in the sera of patients with Schistosoma mansoni and Fasciola infections: Bull. High Instit Pub. Health. Vol XIV. (4), (1984).
31. A.A. Saad M. Ragab. S.M. El-Zoghby and S.I. Fikry: Neonatal serum β-glucuronidase activity and gestational age: Bull. High Inst. Pub. Heal. Vol. XV (3), 112 (1985).
32. Z.A. El-Kholy, A.A. Saad. M.M. Rashad and N.El-Dardiry: The biochemical and histopathological studies on endometrium and vaginal fluid of copper 7200 IUD users two and three years after its insertion: Bull. High Instit. Pub Health. Vol XV (1), 125 (1985).
33. Z.A. El-Kholy, M.M. Rashad, A.M. El-Sharkawy, A.A. Saad, and S.M. El-Zoghby: Biochemical studies on the in vivo effects of some insecticides on liver and spleen β-glucuronidase enzyme activity in murine: Bull. High Inst. Pub. Health. Vol. XV (3), 36 (1985).
34. M.M. Rashad, Z.A. El-Kholy, A.M. El-Sarkawi and A.A, Saad: The effect of some Insecticides on α-Naphthyl Acetate Esterase Activity of Murine Liver and Spleen Tissue Homogenates: Bull. High. Instit. Pub. Health, Vol. Xv (4), 39 (1985).
35. A.A. Saad, Z.A. El-Kholy, A.E. El-Habet. M.M. Rashad and N. El-Dardiry: Effect of long-term Oral Cotraceptive Therapy on the β-glucuronidase Enzyme Activity: Second National Conference of Biochemistry, 11-12 Nov., 1985.
36. A.A. Saad, Z.A. El-Kholy. N. Abou-Rawash. M.E. Salem, M.M. Rashade, A.E. El-Habet: Biochemical Studies on the Lipid Levels and some Lysosomal Enzyme Activities in Atherosclerotic Patients, with Manifestation in the Limbs: Bull. Alex. Fac. Med. Vol. XVII (3), 725 (1986).
37. A.A. Saad. A.E. El-Habet, M.M. Rashad, N.M. Abou-Rawash, and Z.A. El-Kholy: Biochemical Studies on β-glucuronidase Enzyme and Lipid Patterns in Old Ischaemic Heart and Myocardial Infraction Patients; Egypt. J. Med. Sci., 7(2) 645-656 (1986).
38. Z.A. El-Kholy, M.M. Rashad. S.Z. Abdel-Rahman. N.M. Fikry and Effect of Gamma Radiation with and without Radio-Protector Imidazole on Kynurenine Metabolism: Egypt. J. Med. Sci 7 (2), 657-666(1986).
39. Abou-Rawash N.M., Soliman M.H., Al-Habet A., Saad A.A and Megahed M.: Biochemical studies on the effect of hormonal contraceptives on blood lipids and lipoproteins: Egypt, J. Med. Sci. 9(1), 37-46 (1988).
40. Hassan E., Sultan H., Rashad M., and Saad A.A.: β-glucuronidase enzyme activity in synovial fluid from patients with rheumatoid arthritis and osteoarthritis: correlation with humoral immunity: Egypt. Rhemat. & Rehab. 16(2), 169 (1989).
41. Megahed N.A., Zakia A.A., Rashad M.M. and Saad A.A. Changes in β-glucuronidase and complement C3 under anathesia in schistosomal and non-schistosomal patients. Bull. High Inst. Pub. Health, Vol. XX, (2), 347-361 (1990).
42. Samia A. Ebied. Mervat A. El-Touky. Mohamed E. Salem. Zeinate A. El-Kholy. Mona M. Rashad and Aziza A. Saad: Biochemical studies on some lysosomal enzymes in spleen tissue homogenates of hepatosplenic bilharziasis: Bulletin Alex. Fac. Med., XXVII (3): 527-533(1991).
43. Mervat A. El-Toukhy. Samia A. Ebied. Sherif Z. Abdel- Rahman, Aziza A. Saad, Safinax M. El-Zoghby, and Gamal A. Abdel-Tawab: Possible toxicological hazards of some insecticides on kynurenine metabolism in mice. J. Med. Res. Inst. 12(4): supplement (1991).
44. Helmy HH. Micheal Ab. El-Toukhy MA, Ebied SA, and Saad AA: Urinary fibrin/fibrinogen degradation product in patients with benign urological diseases and with bilharzial bladder cancer. J Med. Res Inst. 13(3): 181-190 (1992).
45. Ebied SA, El-Touky MA. El-Zoghby SM, Saad AA. Farag HF. Kandil S, and Ibrahim MM: Studies on serum β-glucroidase activity and urinary tryptophane metabolites in human fascioliasis. J. Trop. Med. Hyg. 96, 151-156 (1993).
46. El-Touky MA. Hussian NG. Mohamed WI. El-Kholy ZA. Abul-Azm T. Saad AA, El-Swedy Sm: Evaluation of serum β-glucuronidase and urinary arylsulphatase A and B as biological markers in bladder cancer patients. Med. Sci. Res. J. 21: 577-578 (1993).
47. Farida, A Mansour, Mohamed. E. Salem, Nabila G. Hussein. Aziza A. Saad and Magda, A. Megahed. The lipid profile of the sera of patients with B^erger’s disease and Atheroscleroisis. J. Med. Res. Inst. Vol., 14(5) (1993).
48. M.A. El-Toukhy. N.G. Hussein. W.I. Mohamed. Z.A. El-Kholy. T. Abul-Azm. A.A. Saad and S.M. El-Sewedy. Evaluation of serum β-glucuronidase and urinary arylsulfatase A & B as biological markers in bladder cancer patients Med. Sci. Res., 1993.21, 577-578.
49. Mohamed E-Salem, Hashim M. Neionaa. Nadia A. Abd El-Meniem and Aizia A. Ibrahim. Alpha-2-antiplasmin (plasmin inhibitor) in the Diagnosis of deep vein thrombosis of the lower limb. J. Med. Res. Instit., 1993, 14 (3) 141-163.
50. Saad, A.A., El-Toukhy, M.A., El-Bakary, A.S., Huessim, N.G., El-Sikali, A.M., Girgis. R.S. and Ramadan M.I. Biochemical and Histopathological studies on the effect of some pesticides on pancreas of male rats. J. Med Res. Instit., 14, 5 (1993).
51. M.A. El-Toukhy, S.A. Ebied, LY. El-Shazly, N.G. Hussein, M.M. Mahdy, T. Abul-Azm and AA Saad. A study on serum adenosine deaminase and urinary arylsufatase activities in squamous and transitional cell carcinoma of bladder cancer patients. Med. Sci. Res., 1994; 22, 271-273.
52. Aziz A. Saad, Nassamat Mohamedeen, Mervat El-Toukhy, Nabila Hussein, Wadida Abel-Wahab, Ashraf Mostafa and Shehata El-Sewedy. Malnutrition diabetes and concomitant pancreatic changes (An experimental study) Egypt J. Med. Lab. Sci, 3 (1), (1994).
53. MH. Helmy, N.A. Sadek, A.M. El-Sharkawy, A.A. Saad, M.E. Salem. Blood level of tissue plasminogen activator (T.P.A) a delicate biochemical indicator of deep vein thrombosis (D.V.T) J. Med. Res. Inst., 16(1), 1995.
54. A.A. Saad, LM. Abou-Basha, LH El-Sayed, M. Abou El-Hoda and A. Youssef. Adenosine deaminase and its correlation to T-lymphocytes in patients with fascioliasis. Egypt J. Med Sci 17 (2) 1996: 567-576.
55. Saad AA, El-Sewedy SM, Helmy MMH, Assem NM, Demian SR, Abu-Seif H and El-Sikaily. Effect of polluted fish intake on interlukin 1, 2 production, phagocytic function of mononuclear phagocytes and liver β-glucuronidase in rats. J. Med. Res. Inst., 1998; 19(2).
56. Hssein NG, Saad AA, Hashem SA and El-Sewedy SM. The effect of dimethyinitrosamnie on the activities of renal phenolsulfotransferase and arysulfatase A and B in Schistosoma mansoni infected mice. J. Egypt. Pub Health Assoc. 1998; LXXIII (5, 6): 691-705.

Supervision of Thesis
1. M.Sc. Thesis
• Studies of the effect of hormonal contraceptives on blood lipids and lipoproteins (1988).
• Biochemical and histopathological studies on the effect of some pesticides on liver and pancreas of rates (1990).
• Evaluation of serum β-glucuronidase and urinary arylsulfatase as biological markers in bladder cancer patients (1991).
• A study on arylsulfatase and adenosine deaminase enzyme activities in bladder cancer patients (1991).
• Biochemical and histopathological studies on ingested tryptophane induced diabetes (1993).
• Effect of adjuvant chemotherapy (CMF) on the hormonal milieu and β-glucuronidase activity of breast cancer premenopausal patients (1993).
• Biochemical studies on β-glucuronidase and α-esteraseas markers of T-lymphocytes maturation in experimental schistosomiasis (1994).
• Biochemical studies on alpha 2-antiplamsmin in the blood of patients with deep vein thrombosis of lower limb (1994).
• Biochemical study on tissues plasminogen activator in the blood of patients with deep vein thrombosis (DVT) of lower limb (1994).
• Biochemical study on serum arylsulfase (A) and IgE in patients with fascioliasis.
• Biochemical study of adenosine deaminase and its correlation to T-lymphocytes in patients with fasciolasis (1995).
• Functional characterization of the top 2 human tumor marker: Identification of potential ligands for GP50/Trop-2 and set up of a murine model GP50/Trop-2 dependent neoplastic growth (1995).
• The effect of DMN on the activities of renal sulfotransferase and arylsulfatase “A” and “B” activities and interleukin-1 level in liver diseases (1996).
• Biochemical study on γ-glutamy1 transpeptidase, glutathione Ѕ-transferase and biomonitoring of hemoglobin-adduct in schistosoma infected mice daily intake polluted fish (1996) .
• Prevalence of diabetes mellitus among school children in Sana’a city, Republicof Yemen (1997).
• Biochemical study on serum arylsultates “A” and its correlation with “IgE” in patients with fascilosis before and after triclabendazole treatment (1999).
• Risk assessment of aquatic environment pollutants on the population health (1999).
• The biochemical and genotoxic effects of occupational exposure to vinyl chloride monomer (1999).
• Hemoglobin-adducts and urinary metabolites of some aromatic amines as biomarkers of exposure (2000).
• The effect of the supplementation of antioxidants on oxidative stress in non insulin dependent diabetes mellitus (NIDDM) (2001).
• The biological activity resulting from the exposure to aquatic environmental gentoxic pollutant (2001).
• A study of the relation of some environmental pollutants and/or cytomegalovirus to recurrent spontaneous abortion (2003).
• Environmental influence on recurrent abortions (2003).
• Effect of low level laser therapy on some hematological factors and lipid per oxidation (2003).
• Effect of low level laser therapy on alcoholic liver injury in rats (2003).
• The effect of antioxidants on experimental fibro genesis using hyaluronic acid as a marker (2005).
• Attenuation of carbon tetrachloride induced hepatic fibrosis by low level laser therapy and glycine (2005).
• Determination of urinary polycyclic aromatic hydrocarbons metabolites as biomarkers of exposure to environmental marine pollution (2008).

2. PhD Thesis
• Studies on the effect of some organic phosphorus and parathyroid insecticides on the kynurenin metabolizing enzymes in vitro (1985).
• Studies on serum β-glucuronidase activity and urinary tryptophan metabolites in human fascioliasis (1990).
• Biochemical studies on the sera of patients with Burger’s disease and patients with atherosclerosis (1993).
• Detection of some carcinogenic aromatic amines in water environments in west industrial region of Alexandria and their effect on the rates (1996).
• Biochemical study on the occupational exposure to vinyl chloride (1996).
• In vivo and in vitro studies on structural and functional characterization of the mouse Trop-2 gene in tumor growth (1998).
• Predictive values of some atherogenic risk factors in young workers occupationally exposed to vinyl chloride or heavy metals (1998).
• Triclabendazole pharmacokinetics and its effect on active fibro genesis in patients with single and dual infection with fasciolosis and schistosomiasis (1998).
• Study on the effect of vitamin (E, C), glycine and low level laser therapy on experimental hepatic fibregenesis (2004).
• Study on the role of cadmium as a causative agent of miscarriage (2005).
• Metallothionein as a biomarker of metals pollution and gene expression of insulin like growth factor (2007).


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