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Curriculum Vitae view

Personal Details
Name :    Maher Abd EL-Nabi Kamel Ahmad
Department :     Biochemistry
Date of Birth :    3/10/1974
Country of Birth :    Egypt
Job :    Assistant Professor of Biochemistry
E-mail :    maherrashwan@hotmail.com

Affiliation
Professor of Biochemistry
Medical Research Institute
Alexandria University

Qualification
B.SC. Biochemistry, Faculty of Science 1996
MSC Applied Medical Chemistry, Medical Research Institute 2000
PhD Applied Medical Chemistry, Medical Research Institute, 2003

Appointments
• From December 2015 to present
Professor of Biochemistry, Medical Research Institute, Alexandria University
Line of research: The molecular mechanisms of transgeneration of metabolic syndrome and the intrauterine programming for the adult diseases. Also Interested in the molecular biology of liver diseases and cancer.

• From October 2008 to December 2015:
Assistant Professor of Biochemistry, Medical Research Institute, Alexandria University
Line of research: The molecular mechanisms of transgeneration of diabetes and the intrauterine programming for the adult diseases. Also Interested in the molecular biology of liver diseases and leukemias.

• From October 2003 to October 2008:
Lecturer of Biochemistry , Medical Research Institute, Alexandria University.
Line of research: Role of oxidative stress, apoptosis, cycolooxygenases (1 and 2) pathways and related products and vascular growth factors (VEGFA-1 and PlGF) on the development of diabetic embryopathy in rats. Also their role in the development metabolic syndrome and insulin resistance in ovariectomized rats.
• From May 2000 to October 2003:
Assistant Lecturer of Biochemistry, Medical Research Institute, Alexandria University
Line of research: Mechanisms of Diabetes-Induced Embryopathy in rats
• From 1998-2000:
Demonstrator of Biochemistry, Medical Research Institute, Alexandria University
Line of research: Nitric oxide biology and its relation to the complications of renal failure and osteoarthritis.

Courses, Meetings & Conferences
* Courses:
• Basic Biochemistry for Master degree students.
• Molecular Biochemistry Course for Master degree students.
• Medical Biochemistry Course for Ph.D. students.
• Molecular Biochemistry Course for Ph.D. students.

* Participation in conferences:

- Participation as speaker in 8th Annual Scientific Conference of The Egyptian Group of Diabetes. In 24-26th September 2003.
Title “Relationship Between Embryo Malformation and Cellular Oxidation Reduction Status, COX-2 Gene Expression and PGE2 levels in Murine Experimental Diabetic Gestation”
This research paper was selected to be the Winner of First Prize of the conference

- Participation as speaker in Annual Scientific Conference of The Egyptian Society of Biochemistry and Molecular Biology. In 19-20th April 2007.
Title“The Redox Status of Acute Leukemia Patients and Its Role on DNA Base Modifications and Apoptosis”

- Participation as speaker in 13th Conference Medical Research Institute. In 21-23th November 2007.
Title “The Redox Status of Acute Leukemia Patients and Its Role on DNA Base Modifications and Apoptosis”

- Participation by poster in 1st Scientific Conference of Medical Biochemistry Department, Faculty of Medicine , Mansoura University. In 14 February 2008.
Title “ Protective Effects of Antioxidant Adjuvant Treatment with Hormone Replacement Therapy Against Cardiovascular Diseases in Ovariectomized Rats”

- Participation by poster in Annual Scientific Conference of The Egyptian Society of Biochemistry and Molecular Biology. In 22-23rd April 2008.
Title “ The Effects of Celecoxib on Different Biochemical Pathways During Rat Gestation”

- Participation as speaker in The academy of Science for Developing World (TWAS) 11th General Conference in South Africa. In 19-23 October 2009.
Title: “Cyclooxygenase Pathway and Its Relationship to Some Growth Factors in Experimental Diabetic Gestation”
- Participation as moderator in Biovision Alex . In 13-15 April 2010 .

- Participation by poster in The academy of Science for Developing World (TWAS) 22nd General Conference in Italy. In 21-23 November 2011
Title: “Prenatal effects of different intra-uterine milieu on fetal glucose sensing mechanisms during gestation in rats”




* Conferences Attendance:
- 8th Annual Scientific Conference of The Egyptian Group of Diabetes. In 24-26th September 2003.
- 6th Pan Arab Congress of Endocrinology and Diabetes. In Bibliotheca Alexandria. In 2-4th March 2005.
- 10th Conference Medical Research Institute (Recent Diagnostic and Therapeutic Approaches).In 8-10th October 2003
- 11th Conference Medical Research Institute(Evidence-Based Medicine). In 23-25th November 2005.
- 4th Integrated Symposium of The Egyptian Association of Advancement of Medical Basic Sciences (Physical Exercise in Health and Diseases). In 13th February 2006.
- 12th Conference Medical Research Institute (Advances in Medical Research). In 22-24th November 2006
- 4th Annual Scientific Conference in Recent Advances in Laboratory Medicine. In 18-21st April 2006.
- 5th Integrated Symposium of The Egyptian Association of Advancement of Medical Basic Sciences (Breast Cancer; Hope and Cure). In 26th February 2007.
- Annual Scientific Conference of The Egyptian Society of Biochemistry and Molecular Biology. In 19-20th April 2007.
- 13th Conference Medical Research Institute (Advances in Medical Research; Liver Diseases ). In 21-23 November 2007.
- 1st Scientific Conference of Medical Biochemistry Department, Faculty of Medicine , Mansoura University. In 14 February 2008.
- Annual Scientific Conference of The Egyptian Society of Biochemistry and Molecular Biology (Human Genome: A Revolution in Modern Biochemistry). In 22-23rd April 2008.
- 14th Conference Medical Research Institute (Advances in Medical Research; oncology ). In 29-31 October 2008.
- Participation by poster in The academy of Science for Developing World (TWAS) 21th General Conference in India. In 19-23 September 2010

Publications
1- Hassan M Fayed, Maher A Kamel, Magda M Sultan, Mohamad N Mowafy, Madiha H Helmy, Saffinaz M EL Zoghby. Nitric Oxide Generation by Peripheral Blood Cells In Chronic Renal Failure. British Journal of Biomedical Science 2002, 59 (1):24-29
2- Hassan M Fayed, Manal Y Tayel, Mona H Abd El Megid, Maher A Kamel. Level of Nitric Oxide in Blood Mononuclear Cells and Plasma of Patients With Rheumatoid Arthritis, Systemic Lupus Erythmatosus and Osteoarthritis. Journal of The Medical Research Institute 2002; 23(2):117-125
3- Emad A EL-Bassiuoni, Madiha H Helmy, Nair Abou Rawash, Saffinaz M EL Zoghby, Maher A Kamel, Anna N Abou Rayah. Embryopathy in experimental diabetic gestation assessment of oxidative stress and antioxidant defense. British Journal of Biomedical Science 2005, 62 (2):71-74
4- Emad A EL-Bassiuoni, Madiha H Helmy, Nair Abou Rawash, Saffinaz M EL Zoghby, Maher A Kamel, Anna N Abou Rayah. Embryopathy in experimental diabetic gestation: assessment of PGE2 level, gene expression of cyclooxygenases and apoptosis. British Journal of Biomedical Science 2005 62 (4):161-165
5- Maher A Kamel, Anna N Abou Rayah, Amal SM Soliman, Mona A salama. Effect of Methotrexate Treatment on Two Markers of Oxidative Stress in Rheumatoid Arthritis. Journal of The Medical Research Institute 2006, 27(2):136-140.
6- Maher A Kamel, Mona Shehata. Effect of Toluene Exposure on Antioxidant Status and Apoptotic Pathway on Organs of Rat. British Journal of Biomedical Science 2008; 65(2): 75-79
7- Saffinaz M EL Zoghby, Madiha H Helmy, Amal M Ghanem, Mervate Y Hanafi, Maher A Kamel, Amal A EL-Sayed. The Status of Antioxidant Defenses in G6PD Deficient Patients. The Role of Antioxidants to Ameliorates Hemolytic Crisis". The Egyptian Journal of Biochemistry and Molecular Biology 2007; 25(2):114-133.
8- Emad A EL-Bassiuoni, Madiha H Helmy, Saffinaz M EL Zoghby, Maher A Kamel, Randa M Hosny. Relationship between levels of circulating modified LDL and the extent of coronary artery disease in type 2 diabetic patients. British Journal of Biomedical Science 2007, 64 (3):109-116.
9- Emad A EL-Bassiuoni, Madiha H Helmy, Evan I Saad, Maher A Kamel, Elham Abdel-Meguid, Hoda SE Hussein. Modulation of the Antioxidant Defenses in Different Developmental Stages of Schistosoma mansoni by Praziquantel and Arthemeter. British Journal of Biomedical Science 2007; 64(4):168-174.
10- Mona Shehata, Maher A Kamel. Protective effect of antioxidant adjuvant treatment with hormone replacement therapy against cardiovascular diseases in ovariectomized rat. Endocrine Regulation 2008; 42:69-75.
11- Nabil Mikhail, Mona Shehata, Maher A Kamel, Mona M Rashad , and Sherin AM Soltan. The Protective effect of antioxidants on renal ischemia-reperfusion injury in the rat. Journal of The Egyptian Society of Endocrinology, Metabolism and Diabetes 2008; 40(1): 191-6.
12- Maher A Kamel, Mervate Y Hanafy, Rowaide R Shehata. The Effect of celecoxib on Different Biochemical Pathways During rat Gestation. Journal of Biophysical and Biomedical Science 2008; 1(1): 13-17
13- Salim MD, Al-Matubsi HY, El-Sharaky AS, Kamel MA, Oriquat GA, Helmy MH, El-Bassiouni EA.. The levels of vascular endothelial growth factor-A and placental growth factor-2 in embryopathy associated with experimental diabetic gestation. Growth Factors 2009; 27(1):32-9.
14- El-Sharaky AS , Newairy AA , Kamel MA , Eweda SM. Protective effect of ginger extract against bromobenzene-induced hepatotoxicity in male rats. Food and Chemical Toxicology 2009; 47: 1584-90.
15- H.Y. Al-Matubsi, M.D. Salim, A.S. El-Sharaky, M.A. Kamel, G.A. Oriquat, M.H. Helmy, E.A. El-Bassiouni and M. Shourbaji. Activities of cyclooxygenases, and levels of prostaglandins E2 And F2α, in fetopathy associated with experimental diabetic gestation. Diabetes and Metabolism 2010; 36: 43–50.
16- Abdel Nasser Ismail Adam, Maher Abdelnabi Kamel and Hossam Ghonaim. Local and Distant Protective Effects of Ischemic Preconditioning Against Renal Ischemia/Reperfusion Injury. Australian Journal of Basic and Applied Sciences 2011, 5(6): 590-596
17- Ahmed Elhefny, Sahar Mourad, Tamer Said Morsi, Maher Abdelnabi Kamel, Haydi Moustafa Mahmoud. Exhaled breath condensate nitric oxide end products and pH in controlled asthma. Egyptian Journal of Chest Diseases and Tuberculosis 2012, 61: 247–256
18- Maher A Kamel. Prenatal effects of different intra-uterine milieus on fetal glucose sensing mechanisms during gestation in rats. Journal of Diabetes and Metabolism 2012: 3:181. doi:10.4172/2155-6156.1000181
19- A.S. El-Sharaky, A.A. Newairy, S.M. Eweda & M.A. Kamel. Bromobenzene-induced hepatotoxicity in male rats: the protective effect of flaxseed. Toxicological and Environmental Chemistry 2012, 94:5, 1000-13
20- Rowaida Refaat, Mona Salama, Maher A Kamel, Sherihan Salah EL Din. The anti-inflammatory and apoptotic effects of atorvastatin in combination with celecoxib in adjuvant-induced arthritis in rats. International Research Journal of Pharmacy and Pharmacology 2013; 3(4): 58-66
21- Maher A. Kamel, Madiha H. Helmy, Anna N. Abou Rayah, Neven Mohand, Huda M. N. Hania. Insulin-Like Growth Factor-1 and Osteocalcin Are Correlated with Markers of Osteoporosis in Postmenopausal Women with Type-2 Diabetes. Open Journal of Endocrine and Metabolic Diseases 2013, 3:245-251
22- MA Kamel, MH Helmy, MY Hanafi, SA Mahmoud, HA Elfetooh. Effect of Maternal Diabetes on Pre-and Post-Natal Redox Status of F1 Rat Offspring. Open Journal of Endocrine and Metabolic Diseases 2014; 4: 111-127
23- Maher A. Kamel, Madiha H. Helmy, Mervat Y. Hanafi, Shimaa A. Mahmoud, Hanan Abo Elfetooh and Mahmoud S. Badr. Maternal Obesity and Malnutrition in Rats Differentially Affect Glucose Sensing in the Muscles and Adipose Tissues in the Offspring. International Journal of Biochemistry Research & Review 2014, 4(5):440-469
24- Maher A. Kamel & Madiha H. Helmy & Mervat Y. Hanafi & 8 Shimaa A. Mahmoud & Hanan Abo Elfetooh. Impaired peripheral glucose sensing in F1 offspring of diabetic pregnancy. Journal of Physiology and Biochemistry 2014; 70 (3): 685-699. DOI 10.1007/s13105-014-0338-z
25- Mohamed I Saad, Maher A Kamel, Mervat Y Hanafi, Madiha H Helmy, Rowaida R Shehata. Effect of Sitagliptin and Glimepiride on Glucose Homeostasis and cAMP Levels in Peripheral Tissues of HFD/STZ Diabetic Rats. American Journal of Biomedical Research, 2014, Vol. 2, No. 3, 52-60
26- Maher A. Kamel, Shimaa A. Mahmoud, Hanan Abo Elfetooh. In-utero exposure to maternal diabetes increase the risk of vascular diseases in the F1 offspring in rats. American Journal of Biomedical Sciences, 2014; 6(3):201-216.
27- Mohamed I. Saad, Maher A. Kamel, and Mervat Y. Hanafi. Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats. Biochemistry Research International, Volume 2015, Article ID 138134, http://dx.doi.org/10.1155/2015/138134
28- Shady H. Tawfik, Bothaina F. Mahmoud, Mohamed I. Saad, Mona Shehata, Maher A. Kamel, and Madiha H. Helmy. Similar and Additive Effects of Ovariectomy and Diabetes on Insulin Resistance and Lipid Metabolism. Biochemistry Research International 2015, Article ID 567945, http://dx.doi.org/10.1155/2015/567945
29- Mohamed I. Saad, Maher A. Kamel, Taha M. Abdelkhalek, Moustafa M. Saleh and Shady H. Tawfik. Recent Patents and Advances in Regenerative Medicine and Stem Cell Therapies for Diabetes, Cardiovascular and Neurodegenerative Diseases. Recent Patents on Regenerative Medicine 2015;5:36-54. DOI: 10.2174/2210296505666150520224033
30- Mennatallah A Ali, Hanan S Al-Abhar, Maher A Kamel, Ahmed Attia. Antidiabetic effect of Galantamine: Novel effect for a known centrally acting drug. PLOS ONE 2015, 10(8): e0134648. doi:10.1371/journal.pone.0134648
31- Nevien Mahmoud Ahmed, Madeha Hassan Helmy, Maher AbdEl-Naby Kamel, Mervat Youssef Hanafy. Role of Adipocytokines in the Induction of Experimental ‎Non Alcoholic Fatty Liver Disease‎. American Journal of Medicine and Medical Sciences 2015, 5(4): 175-180. DOI: 10.5923/j.ajmms.20150504.06
32- Anna N Abou-Rayaa, Maher A Kamel, Eman A Sayed, Ahmed A El-Sharkawy. The plasma level of soluble receptor for advanced glycation end products in systemic lupus erythematosus patients and its relation to disease activity. Alex J Med 2015: in press (http://dx.doi.org/10.1016/j.ajme.2015.06.005)
33- Mohamed I. Saad, Taha M. Abdelkhalek, Moustafa M. Saleh, Maher A. Kamel, Mina Youssef, Shady H. Tawfik, Helena Dominguez. Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells. Endocrine 2015, 50(3): 537-567. DOI 10.1007/s12020-015-0709-4
34- Mohamed I. Saad , Taha M. Abdelkhalek, Maha M. Haiba, Moustafa M. Saleh, Mervat Y. Hanafi, Shady H. Tawfik, Maher A. Kamel. Maternal Obesity and Malnourishment Exacerbate Perinatal Oxidative Stress Resulting in Diabetogenic Programming in F1 Offspring. Journal of Endocrinological Investigation 2015; DOI:10.1007/s40618-015-0413-5
35- Hanafi MY, Saleh MM, Saad MI, Abdelkhalek TM, Kamel MA. Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Mol Cell Biochem. 2015 Dec 26: 10.1007/s11010-015-2633-6
36- Mervat Y. Hanafi , Taha M Abdelkhalek , Mohamed I. Saad, Moustafa M. Saleh, Maher A. Kamel. Diabetes-Induced Perturbations are Subject To Transgenerational Transmission Through Maternal Line. Journal of Physiology and Biochemistry 2016; April: in press. DOI 10.1007/s13105-016-0483-7
37- Mervat Y. Hanafi , Mohamed I. Saad, Taha M Abdelkhalek , Moustafa M. Saleh, Maher A. Kamel. In-Utero Nutritional Manipulation Provokes Dysregulated Adipocytokines Production in F1 Offspring in Rats. Scientifica 2016; Article ID 3892890, 9 pages. http://dx.doi.org/10.1155/2016/3892890
38- Mohamed I. Saad , Taha M. Abdelkhalek, Moustafa M. Saleh, Maha M. Haiba, Shady H. Tawfik, Maher A. Kamel. Maternal diabetes impairs oxidative and inflammatory response in murine placenta. SpringerPlus 2016; 5:532

Supervision of Thesis
- Master Thesis: 50 Thesis in the field of Biochemistry, Molecular biology, Applied medical chemistry, Pharmacology, Parasitology, Internal Medicine, Rheumatology and Gerontology.

- PhD Thesis: 20 Thesis in the field of Biochemistry, Molecular biology, Applied medical chemistry, Pharmacology, Parasitology, Internal Medicine, Rheumatology and Gerontology.

Experiences
- Routine Cell Culture
- PCR, RT-PCR
- basics of recombinant DNA technology
- molecular weight determination of protein by PAGE electrophoresis
- Cell separation
- Hepatic drug metabolism
- Assay of apoptosis, angiogenesis, growth factors, lipid mediators, and cyclooxygenases pathways.
- Adipose tissues metabolism
- Induction of experimental models of diabetes (Type 1 and 2)
- Induction of animal models of non-alcoholic fatty liver diseases (NAFLD)
- Pancreatic β-cell isolation by collagenase digestion method
- mitochobdrial DNA isolation and also quantification of mitochondrial DNA copy number

Others
* Selected as a TWAS Young Affiliate Fellow by TWAS (The Academy of Sciences For Developing World) and the TWAS Regional Office for the Arab Region (TWAS-ARO) in 2009
* Member of the Editorial board of
- International Journal of Molecular Biology and Biochemistry (IJMBB)(http://www.irphouse.com/Editorial%20Board%20Members/ijmbb_Ed_Memb.html)
- Diabetes Research and Treatment: Open Access (http://aperito.org/journal/ebm_display/7)
* Reviewer in:
- Molecular Biology Reports (Springer publisher)
- Nutrition Research (Elsevier Publisher)
- The American Journal of the Medical Sciences (Elsevier Publisher)
- Brazilian Archives Of Biology And Technology (Braz Arch Biol Technol)
- Annual Report and Review in Biology
- British Journal of Medicine and Medical Research (Sciencedomain International publisher)
- Nutrition and Metabolism

* Principle Investigator of the project entitled: "Intra-Uterine Programming of Adult diabetes: An Experimental Study" funded by STDF during the period of 2009-2012


Alexandria University Alexandria University