| Subject |
Filaggrin Gene Polymorphisms in Egyptian Atopic Dermatitis Patients |
| Authors |
Mohamed NS and Hashad DI |
| Code |
2010 -
vol. 31,
No. 1,
Page. 19
|
| Type |
Research Article
|
|
| FILE #1 : 19-23_.pdf (165.1K), Down:6078, 2011-09-12 03:20:09 |
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Background: Atopic dermatitis is a skin condition that follows a chronic
relapsing course and is predisposed to by loss-of-function mutations of
FLG gene in several Caucasian cohorts.
Aim: This work was carried out to study if R501X and 2282del4
polymorphisms of FLG gene contribute towards susceptibility to atopic
dermatitis in Egyptian patients.
Methods: A cohort of 99 Egyptian atopic dermatitis patients and 75 age
and sex matched healthy control subjects were evaluated for R501X and
2282del4 null alleles.
Results: Genotyping of R501X and 2282del4 polymorphisms in AD
patients and controls showed similar frequency of risk alleles of 0%.
Conclusions: The present findings suggest that risk alleles of R501X and
2282del4 in Alexandria as an Example of Egyptian atopic dermatitis
patients can’t be correlated to disease occurrence
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